{ "collection": "ImmPrint", "version": "0.2.0-alpha", "n_gene_sets": 44, "n_pairs": 720, "generated": "2026-06-20", "records": [ { "gene_set": "IMMPRINT_ANGIOGENESIS", "gene_symbol": "VEGFA", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2479986" ], "reference_gene_set": "HALLMARK_ANGIOGENESIS" }, { "gene_set": "IMMPRINT_ANGIOGENESIS", "gene_symbol": "VEGFB", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8637916" ], "reference_gene_set": "GOBP_SPROUTING_ANGIOGENESIS" }, { "gene_set": "IMMPRINT_ANGIOGENESIS", "gene_symbol": "VEGFC", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8617204" ], "reference_gene_set": "GOBP_SPROUTING_ANGIOGENESIS" }, { "gene_set": "IMMPRINT_ANGIOGENESIS", "gene_symbol": "PGF", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1924389" ], "reference_gene_set": "GOBP_SPROUTING_ANGIOGENESIS" }, { "gene_set": "IMMPRINT_ANGIOGENESIS", "gene_symbol": "FLT1", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7596436" ], "reference_gene_set": "GOBP_SPROUTING_ANGIOGENESIS" }, { "gene_set": "IMMPRINT_ANGIOGENESIS", "gene_symbol": "KDR", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1417831" ], "reference_gene_set": "GOBP_SPROUTING_ANGIOGENESIS" }, { "gene_set": "IMMPRINT_ANGIOGENESIS", "gene_symbol": "FLT4", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "10856194" ], "reference_gene_set": "GOBP_SPROUTING_ANGIOGENESIS" }, { "gene_set": "IMMPRINT_ANGIOGENESIS", "gene_symbol": "NRP1", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9529250" ], "reference_gene_set": "HALLMARK_ANGIOGENESIS" }, { "gene_set": "IMMPRINT_ANGIOGENESIS", "gene_symbol": "ANGPT1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8980223" ], "reference_gene_set": "GOBP_SPROUTING_ANGIOGENESIS" }, { "gene_set": "IMMPRINT_ANGIOGENESIS", "gene_symbol": "ANGPT2", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "context_dependent", "cell_type": "pan", "pmids": [ "9204896" ], "reference_gene_set": "GOBP_ENDOTHELIAL_CELL_MIGRATION" }, { "gene_set": "IMMPRINT_ANGIOGENESIS", "gene_symbol": "TEK", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8980225" ], "reference_gene_set": "GOBP_SPROUTING_ANGIOGENESIS" }, { "gene_set": "IMMPRINT_ANGIOGENESIS", "gene_symbol": "TIE1", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1312667" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_ANGIOGENESIS", "gene_symbol": "CDH5", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7627717" ], "reference_gene_set": "GOBP_SPROUTING_ANGIOGENESIS" }, { "gene_set": "IMMPRINT_ANGIOGENESIS", "gene_symbol": "PECAM1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9284815" ], "reference_gene_set": "GOBP_ENDOTHELIAL_CELL_MIGRATION" }, { "gene_set": "IMMPRINT_ANGIOGENESIS", "gene_symbol": "HIF1A", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8756616" ], "reference_gene_set": "GOBP_ENDOTHELIAL_CELL_MIGRATION" }, { "gene_set": "IMMPRINT_ANGIOGENESIS", "gene_symbol": "EPAS1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9000051" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_ANGIOGENESIS", "gene_symbol": "FGF2", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "3780670" ], "reference_gene_set": "GOBP_SPROUTING_ANGIOGENESIS" }, { "gene_set": "IMMPRINT_ANGIOGENESIS", "gene_symbol": "DLL4", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "inhibitory", "cell_type": "pan", "pmids": [ "10837024" ], "reference_gene_set": "GOBP_SPROUTING_ANGIOGENESIS" }, { "gene_set": "IMMPRINT_APOPTOSIS_EXTRINSIC", "gene_symbol": "FAS", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1713127" ], "reference_gene_set": "REACTOME_DEATH_RECEPTOR_SIGNALING" }, { "gene_set": "IMMPRINT_APOPTOSIS_EXTRINSIC", "gene_symbol": "TNFRSF10A", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9082980" ], "reference_gene_set": "REACTOME_DEATH_RECEPTOR_SIGNALING" }, { "gene_set": "IMMPRINT_APOPTOSIS_EXTRINSIC", "gene_symbol": "TNFRSF10B", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9242611" ], "reference_gene_set": "REACTOME_DEATH_RECEPTOR_SIGNALING" }, { "gene_set": "IMMPRINT_APOPTOSIS_EXTRINSIC", "gene_symbol": "TNFRSF1A", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8397073" ], "reference_gene_set": "REACTOME_DEATH_RECEPTOR_SIGNALING" }, { "gene_set": "IMMPRINT_APOPTOSIS_EXTRINSIC", "gene_symbol": "FADD", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7538907" ], "reference_gene_set": "REACTOME_DEATH_RECEPTOR_SIGNALING" }, { "gene_set": "IMMPRINT_APOPTOSIS_EXTRINSIC", "gene_symbol": "TRADD", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7758105" ], "reference_gene_set": "REACTOME_DEATH_RECEPTOR_SIGNALING" }, { "gene_set": "IMMPRINT_APOPTOSIS_EXTRINSIC", "gene_symbol": "CASP8", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8681377" ], "reference_gene_set": "REACTOME_DEATH_RECEPTOR_SIGNALING" }, { "gene_set": "IMMPRINT_APOPTOSIS_EXTRINSIC", "gene_symbol": "CASP10", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8755496" ], "reference_gene_set": "REACTOME_DEATH_RECEPTOR_SIGNALING" }, { "gene_set": "IMMPRINT_APOPTOSIS_EXTRINSIC", "gene_symbol": "CASP3", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7596430" ], "reference_gene_set": "REACTOME_DEATH_RECEPTOR_SIGNALING" }, { "gene_set": "IMMPRINT_APOPTOSIS_EXTRINSIC", "gene_symbol": "CASP6", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7796396" ], "reference_gene_set": "REACTOME_APOPTOSIS" }, { "gene_set": "IMMPRINT_APOPTOSIS_EXTRINSIC", "gene_symbol": "CASP7", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8521391" ], "reference_gene_set": "REACTOME_APOPTOSIS" }, { "gene_set": "IMMPRINT_APOPTOSIS_EXTRINSIC", "gene_symbol": "BID", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9727492" ], "reference_gene_set": "REACTOME_APOPTOSIS" }, { "gene_set": "IMMPRINT_APOPTOSIS_EXTRINSIC", "gene_symbol": "CFLAR", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "inhibitory", "cell_type": "pan", "pmids": [ "9217161" ], "reference_gene_set": "REACTOME_DEATH_RECEPTOR_SIGNALING" }, { "gene_set": "IMMPRINT_APOPTOSIS_EXTRINSIC", "gene_symbol": "BIRC2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "inhibitory", "cell_type": "pan", "pmids": [ "18022362" ], "reference_gene_set": "REACTOME_DEATH_RECEPTOR_SIGNALING" }, { "gene_set": "IMMPRINT_APOPTOSIS_EXTRINSIC", "gene_symbol": "BIRC3", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "inhibitory", "cell_type": "pan", "pmids": [ "18022362" ], "reference_gene_set": "REACTOME_DEATH_RECEPTOR_SIGNALING" }, { "gene_set": "IMMPRINT_APOPTOSIS_INTRINSIC", "gene_symbol": "BCL2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "inhibitory", "cell_type": "pan", "pmids": [ "2250705" ], "reference_gene_set": "REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS" }, { "gene_set": "IMMPRINT_APOPTOSIS_INTRINSIC", "gene_symbol": "BCL2L1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "inhibitory", "cell_type": "pan", "pmids": [ "8358789" ], "reference_gene_set": "REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS" }, { "gene_set": "IMMPRINT_APOPTOSIS_INTRINSIC", "gene_symbol": "MCL1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "inhibitory", "cell_type": "pan", "pmids": [ "7682708" ], "reference_gene_set": "GOBP_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA" }, { "gene_set": "IMMPRINT_APOPTOSIS_INTRINSIC", "gene_symbol": "BCL2L2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "inhibitory", "cell_type": "pan", "pmids": [ "8761287" ], "reference_gene_set": "GOBP_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA" }, { "gene_set": "IMMPRINT_APOPTOSIS_INTRINSIC", "gene_symbol": "BAX", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8358790" ], "reference_gene_set": "REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS" }, { "gene_set": "IMMPRINT_APOPTOSIS_INTRINSIC", "gene_symbol": "BAK1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7715730" ], "reference_gene_set": "REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS" }, { "gene_set": "IMMPRINT_APOPTOSIS_INTRINSIC", "gene_symbol": "BAD", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7834748" ], "reference_gene_set": "REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS" }, { "gene_set": "IMMPRINT_APOPTOSIS_INTRINSIC", "gene_symbol": "BID", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8918887" ], "reference_gene_set": "REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS" }, { "gene_set": "IMMPRINT_APOPTOSIS_INTRINSIC", "gene_symbol": "BBC3", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "11463392" ], "reference_gene_set": "REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS" }, { "gene_set": "IMMPRINT_APOPTOSIS_INTRINSIC", "gene_symbol": "PMAIP1", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "10807576" ], "reference_gene_set": "REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS" }, { "gene_set": "IMMPRINT_APOPTOSIS_INTRINSIC", "gene_symbol": "BCL2L11", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9430630" ], "reference_gene_set": "REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS" }, { "gene_set": "IMMPRINT_APOPTOSIS_INTRINSIC", "gene_symbol": "BMF", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "11546872" ], "reference_gene_set": "REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS" }, { "gene_set": "IMMPRINT_APOPTOSIS_INTRINSIC", "gene_symbol": "HRK", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9130713" ], "reference_gene_set": "GOBP_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA" }, { "gene_set": "IMMPRINT_APOPTOSIS_INTRINSIC", "gene_symbol": "BIK", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7478623" ], "reference_gene_set": "GOBP_RELEASE_OF_CYTOCHROME_C_FROM_MITOCHONDRIA" }, { "gene_set": "IMMPRINT_APOPTOSIS_INTRINSIC", "gene_symbol": "APAF1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9267021" ], "reference_gene_set": "REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS" }, { "gene_set": "IMMPRINT_APOPTOSIS_INTRINSIC", "gene_symbol": "CYCS", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8689682" ], "reference_gene_set": "REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS" }, { "gene_set": "IMMPRINT_APOPTOSIS_INTRINSIC", "gene_symbol": "DIABLO", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "10929711" ], "reference_gene_set": "REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS" }, { "gene_set": "IMMPRINT_APOPTOSIS_INTRINSIC", "gene_symbol": "CASP9", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9390557" ], "reference_gene_set": "REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS" }, { "gene_set": "IMMPRINT_APOPTOSIS_INTRINSIC", "gene_symbol": "CASP3", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7596430" ], "reference_gene_set": "REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS" }, { "gene_set": "IMMPRINT_APOPTOSIS_INTRINSIC", "gene_symbol": "CASP7", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8521391" ], "reference_gene_set": "REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS" }, { "gene_set": "IMMPRINT_APOPTOSIS_INTRINSIC", "gene_symbol": "XIAP", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "inhibitory", "cell_type": "pan", "pmids": [ "9230442" ], "reference_gene_set": "REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS" }, { "gene_set": "IMMPRINT_APOPTOSIS_INTRINSIC", "gene_symbol": "TP53", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7834749" ], "reference_gene_set": "REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS" }, { "gene_set": "IMMPRINT_BCR_SIGNALLING", "gene_symbol": "CD79A", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "B cell", "pmids": [ "2463161" ], "reference_gene_set": "REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR" }, { "gene_set": "IMMPRINT_BCR_SIGNALLING", "gene_symbol": "CD79B", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "B cell", "pmids": [ "3137575" ], "reference_gene_set": "REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR" }, { "gene_set": "IMMPRINT_BCR_SIGNALLING", "gene_symbol": "LYN", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "B cell", "pmids": [ "1702903" ], "reference_gene_set": "REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR" }, { "gene_set": "IMMPRINT_BCR_SIGNALLING", "gene_symbol": "SYK", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "B cell", "pmids": [ "33782605" ], "reference_gene_set": "REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR" }, { "gene_set": "IMMPRINT_BCR_SIGNALLING", "gene_symbol": "BTK", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "B cell", "pmids": [ "8425221" ], "reference_gene_set": "REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR" }, { "gene_set": "IMMPRINT_BCR_SIGNALLING", "gene_symbol": "BLNK", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "B cell", "pmids": [ "9697839" ], "reference_gene_set": "REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR" }, { "gene_set": "IMMPRINT_BCR_SIGNALLING", "gene_symbol": "PLCG2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "B cell", "pmids": [ "22236196" ], "reference_gene_set": "REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR" }, { "gene_set": "IMMPRINT_BCR_SIGNALLING", "gene_symbol": "PIK3CD", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "B cell", "pmids": [ "24136356" ], "reference_gene_set": "REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR" }, { "gene_set": "IMMPRINT_BCR_SIGNALLING", "gene_symbol": "PIK3R1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "B cell", "pmids": [ "25133428" ], "reference_gene_set": "REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR" }, { "gene_set": "IMMPRINT_BCR_SIGNALLING", "gene_symbol": "AKT1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "B cell", "pmids": [ "10438924", "10521450" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_BCR_SIGNALLING", "gene_symbol": "CARD11", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "B cell", "pmids": [ "11278692" ], "reference_gene_set": "REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR" }, { "gene_set": "IMMPRINT_BCR_SIGNALLING", "gene_symbol": "BCL10", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "B cell", "pmids": [ "25365219" ], "reference_gene_set": "REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR" }, { "gene_set": "IMMPRINT_BCR_SIGNALLING", "gene_symbol": "MALT1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "B cell", "pmids": [ "23727036" ], "reference_gene_set": "REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR" }, { "gene_set": "IMMPRINT_BCR_SIGNALLING", "gene_symbol": "NFATC1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "B cell", "pmids": [ "8202141" ], "reference_gene_set": "REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR" }, { "gene_set": "IMMPRINT_BCR_SIGNALLING", "gene_symbol": "NFKB1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "B cell", "pmids": [ "1992489" ], "reference_gene_set": "REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR" }, { "gene_set": "IMMPRINT_BCR_SIGNALLING", "gene_symbol": "RELA", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "B cell", "pmids": [ "2125960" ], "reference_gene_set": "REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR" }, { "gene_set": "IMMPRINT_BCR_SIGNALLING", "gene_symbol": "VAV1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "B cell", "pmids": [ "7700358" ], "reference_gene_set": "REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR" }, { "gene_set": "IMMPRINT_CGAS_STING_SIGNALLING", "gene_symbol": "CGAS", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "23258413" ], "reference_gene_set": "REACTOME_STING_MEDIATED_INDUCTION_OF_HOST_IMMUNE_RESPONSES" }, { "gene_set": "IMMPRINT_CGAS_STING_SIGNALLING", "gene_symbol": "STING1", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "18724357" ], "reference_gene_set": "REACTOME_STING_MEDIATED_INDUCTION_OF_HOST_IMMUNE_RESPONSES" }, { "gene_set": "IMMPRINT_CGAS_STING_SIGNALLING", "gene_symbol": "TBK1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "22394562" ], "reference_gene_set": "REACTOME_STING_MEDIATED_INDUCTION_OF_HOST_IMMUNE_RESPONSES" }, { "gene_set": "IMMPRINT_CGAS_STING_SIGNALLING", "gene_symbol": "IKBKE", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "12692549" ], "reference_gene_set": "REACTOME_DDX58_IFIH1_MEDIATED_INDUCTION_OF_INTERFERON_ALPHA_BETA" }, { "gene_set": "IMMPRINT_CGAS_STING_SIGNALLING", "gene_symbol": "IRF3", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "22394562" ], "reference_gene_set": "REACTOME_STING_MEDIATED_INDUCTION_OF_HOST_IMMUNE_RESPONSES" }, { "gene_set": "IMMPRINT_CGAS_STING_SIGNALLING", "gene_symbol": "NFKB1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "24600004" ], "reference_gene_set": "REACTOME_DDX58_IFIH1_MEDIATED_INDUCTION_OF_INTERFERON_ALPHA_BETA" }, { "gene_set": "IMMPRINT_CGAS_STING_SIGNALLING", "gene_symbol": "RELA", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "24600004" ], "reference_gene_set": "REACTOME_DDX58_IFIH1_MEDIATED_INDUCTION_OF_INTERFERON_ALPHA_BETA" }, { "gene_set": "IMMPRINT_CGAS_STING_SIGNALLING", "gene_symbol": "IFNB1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "25029335" ], "reference_gene_set": "REACTOME_DDX58_IFIH1_MEDIATED_INDUCTION_OF_INTERFERON_ALPHA_BETA" }, { "gene_set": "IMMPRINT_CGAS_STING_SIGNALLING", "gene_symbol": "TREX1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "inhibitory", "cell_type": "pan", "pmids": [ "26223655" ], "reference_gene_set": "REACTOME_STING_MEDIATED_INDUCTION_OF_HOST_IMMUNE_RESPONSES" }, { "gene_set": "IMMPRINT_CGAS_STING_SIGNALLING", "gene_symbol": "ENPP1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "inhibitory", "cell_type": "pan", "pmids": [ "25344812", "30356045" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_COMPLEMENT_PRODUCTION", "gene_symbol": "C1QA", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1706597" ], "reference_gene_set": "REACTOME_COMPLEMENT_CASCADE" }, { "gene_set": "IMMPRINT_COMPLEMENT_PRODUCTION", "gene_symbol": "C1QB", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1706597" ], "reference_gene_set": "REACTOME_COMPLEMENT_CASCADE" }, { "gene_set": "IMMPRINT_COMPLEMENT_PRODUCTION", "gene_symbol": "C1QC", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1706597" ], "reference_gene_set": "REACTOME_COMPLEMENT_CASCADE" }, { "gene_set": "IMMPRINT_COMPLEMENT_PRODUCTION", "gene_symbol": "C1R", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "10092586" ], "reference_gene_set": "REACTOME_COMPLEMENT_CASCADE" }, { "gene_set": "IMMPRINT_COMPLEMENT_PRODUCTION", "gene_symbol": "C1S", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "3500856" ], "reference_gene_set": "REACTOME_COMPLEMENT_CASCADE" }, { "gene_set": "IMMPRINT_COMPLEMENT_PRODUCTION", "gene_symbol": "C2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "6199794" ], "reference_gene_set": "REACTOME_COMPLEMENT_CASCADE" }, { "gene_set": "IMMPRINT_COMPLEMENT_PRODUCTION", "gene_symbol": "C3", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2579379" ], "reference_gene_set": "REACTOME_COMPLEMENT_CASCADE" }, { "gene_set": "IMMPRINT_COMPLEMENT_PRODUCTION", "gene_symbol": "C4A", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "6546707" ], "reference_gene_set": "REACTOME_COMPLEMENT_CASCADE" }, { "gene_set": "IMMPRINT_COMPLEMENT_PRODUCTION", "gene_symbol": "C4B", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "6546707" ], "reference_gene_set": "REACTOME_COMPLEMENT_CASCADE" }, { "gene_set": "IMMPRINT_COMPLEMENT_PRODUCTION", "gene_symbol": "C5", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1984448" ], "reference_gene_set": "REACTOME_COMPLEMENT_CASCADE" }, { "gene_set": "IMMPRINT_COMPLEMENT_PRODUCTION", "gene_symbol": "C6", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2808363" ], "reference_gene_set": "REACTOME_COMPLEMENT_CASCADE" }, { "gene_set": "IMMPRINT_COMPLEMENT_PRODUCTION", "gene_symbol": "C7", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "3335508" ], "reference_gene_set": "REACTOME_COMPLEMENT_CASCADE" }, { "gene_set": "IMMPRINT_COMPLEMENT_PRODUCTION", "gene_symbol": "C8A", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2820471" ], "reference_gene_set": "REACTOME_COMPLEMENT_CASCADE" }, { "gene_set": "IMMPRINT_COMPLEMENT_PRODUCTION", "gene_symbol": "C8B", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2820472" ], "reference_gene_set": "REACTOME_COMPLEMENT_CASCADE" }, { "gene_set": "IMMPRINT_COMPLEMENT_PRODUCTION", "gene_symbol": "C8G", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "3676249" ], "reference_gene_set": "REACTOME_COMPLEMENT_CASCADE" }, { "gene_set": "IMMPRINT_COMPLEMENT_PRODUCTION", "gene_symbol": "C9", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "6095282" ], "reference_gene_set": "REACTOME_COMPLEMENT_CASCADE" }, { "gene_set": "IMMPRINT_COMPLEMENT_PRODUCTION", "gene_symbol": "CFB", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "6957884" ], "reference_gene_set": "REACTOME_COMPLEMENT_CASCADE" }, { "gene_set": "IMMPRINT_COMPLEMENT_PRODUCTION", "gene_symbol": "CFD", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1374388" ], "reference_gene_set": "REACTOME_COMPLEMENT_CASCADE" }, { "gene_set": "IMMPRINT_COMPLEMENT_PRODUCTION", "gene_symbol": "MBL2", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2477486" ], "reference_gene_set": "REACTOME_COMPLEMENT_CASCADE" }, { "gene_set": "IMMPRINT_COMPLEMENT_PRODUCTION", "gene_symbol": "MASP1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1460414" ], "reference_gene_set": "REACTOME_COMPLEMENT_CASCADE" }, { "gene_set": "IMMPRINT_COMPLEMENT_PRODUCTION", "gene_symbol": "MASP2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9087411" ], "reference_gene_set": "REACTOME_COMPLEMENT_CASCADE" }, { "gene_set": "IMMPRINT_COMPLEMENT_PRODUCTION", "gene_symbol": "FCN1", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8573080" ], "reference_gene_set": "REACTOME_COMPLEMENT_CASCADE" }, { "gene_set": "IMMPRINT_COMPLEMENT_PRODUCTION", "gene_symbol": "CFP", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2009915" ], "reference_gene_set": "REACTOME_COMPLEMENT_CASCADE" }, { "gene_set": "IMMPRINT_CTLA4_SIGNALLING", "gene_symbol": "CTLA4", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "7882171" ], "reference_gene_set": "REACTOME_CO_INHIBITION_BY_CTLA4" }, { "gene_set": "IMMPRINT_CTLA4_SIGNALLING", "gene_symbol": "PPP2CA", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "11021529" ], "reference_gene_set": "REACTOME_CO_INHIBITION_BY_CTLA4" }, { "gene_set": "IMMPRINT_CTLA4_SIGNALLING", "gene_symbol": "PPP2R1A", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "11021529" ], "reference_gene_set": "REACTOME_CO_INHIBITION_BY_CTLA4" }, { "gene_set": "IMMPRINT_CTLA4_SIGNALLING", "gene_symbol": "PTPN11", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "8638161" ], "reference_gene_set": "REACTOME_CO_INHIBITION_BY_CTLA4" }, { "gene_set": "IMMPRINT_CTLA4_SIGNALLING", "gene_symbol": "PTPN6", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "23601194" ], "reference_gene_set": "REACTOME_REGULATION_OF_T_CELL_ACTIVATION_BY_CD28_FAMILY" }, { "gene_set": "IMMPRINT_CTLA4_SIGNALLING", "gene_symbol": "CD28", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "7534620" ], "reference_gene_set": "REACTOME_REGULATION_OF_T_CELL_ACTIVATION_BY_CD28_FAMILY" }, { "gene_set": "IMMPRINT_CTLA4_SIGNALLING", "gene_symbol": "AKT1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "16227604" ], "reference_gene_set": "REACTOME_CO_INHIBITION_BY_CTLA4" }, { "gene_set": "IMMPRINT_CTLA4_SIGNALLING", "gene_symbol": "AP2M1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "9256472", "9175836" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_CYTOLYTIC_ACTIVITY", "gene_symbol": "PRF1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "T cell; NK cell", "pmids": [ "10583959" ], "reference_gene_set": "GOBP_CELL_KILLING" }, { "gene_set": "IMMPRINT_CYTOLYTIC_ACTIVITY", "gene_symbol": "GZMA", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "T cell; NK cell", "pmids": [ "3257574" ], "reference_gene_set": "GOBP_CELL_KILLING" }, { "gene_set": "IMMPRINT_CYTOLYTIC_ACTIVITY", "gene_symbol": "GZMB", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "T cell; NK cell", "pmids": [ "3261871" ], "reference_gene_set": "GOBP_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY" }, { "gene_set": "IMMPRINT_CYTOLYTIC_ACTIVITY", "gene_symbol": "GZMH", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "T cell; NK cell", "pmids": [ "2049336" ], "reference_gene_set": "GOBP_CELL_KILLING" }, { "gene_set": "IMMPRINT_CYTOLYTIC_ACTIVITY", "gene_symbol": "GZMM", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "T cell; NK cell", "pmids": [ "7713495" ], "reference_gene_set": "GOBP_CELL_KILLING" }, { "gene_set": "IMMPRINT_CYTOLYTIC_ACTIVITY", "gene_symbol": "GNLY", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "T cell; NK cell", "pmids": [ "2434598" ], "reference_gene_set": "GOBP_CELL_KILLING" }, { "gene_set": "IMMPRINT_CYTOLYTIC_ACTIVITY", "gene_symbol": "NKG7", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell; NK cell", "pmids": [ "32839608" ], "reference_gene_set": "GOBP_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY" }, { "gene_set": "IMMPRINT_CYTOLYTIC_ACTIVITY", "gene_symbol": "KLRK1", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "T cell; NK cell", "pmids": [ "10426993" ], "reference_gene_set": "GOBP_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY" }, { "gene_set": "IMMPRINT_CYTOLYTIC_ACTIVITY", "gene_symbol": "KLRD1", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "T cell; NK cell", "pmids": [ "8943374" ], "reference_gene_set": "GOBP_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY" }, { "gene_set": "IMMPRINT_CYTOLYTIC_ACTIVITY", "gene_symbol": "KLRC2", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "T cell; NK cell", "pmids": [ "2007850" ], "reference_gene_set": "GOBP_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY" }, { "gene_set": "IMMPRINT_CYTOLYTIC_ACTIVITY", "gene_symbol": "CTSW", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "T cell; NK cell", "pmids": [ "11490002", "9108299" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_CYTOLYTIC_ACTIVITY", "gene_symbol": "UNC13D", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell; NK cell", "pmids": [ "14622600" ], "reference_gene_set": "GOBP_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY" }, { "gene_set": "IMMPRINT_CYTOLYTIC_ACTIVITY", "gene_symbol": "STXBP2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell; NK cell", "pmids": [ "19804848" ], "reference_gene_set": "GOBP_CELL_KILLING" }, { "gene_set": "IMMPRINT_CYTOLYTIC_ACTIVITY", "gene_symbol": "RAB27A", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell; NK cell", "pmids": [ "10835631" ], "reference_gene_set": "GOBP_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY" }, { "gene_set": "IMMPRINT_CYTOLYTIC_ACTIVITY", "gene_symbol": "LAMP1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell; NK cell", "pmids": [ "14580882" ], "reference_gene_set": "GOBP_NATURAL_KILLER_CELL_MEDIATED_IMMUNITY" }, { "gene_set": "IMMPRINT_FATTY_ACID_OXIDATION", "gene_symbol": "CPT1A", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7892212" ], "reference_gene_set": "GOBP_FATTY_ACID_BETA_OXIDATION" }, { "gene_set": "IMMPRINT_FATTY_ACID_OXIDATION", "gene_symbol": "CPT2", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1988962" ], "reference_gene_set": "GOBP_FATTY_ACID_BETA_OXIDATION" }, { "gene_set": "IMMPRINT_FATTY_ACID_OXIDATION", "gene_symbol": "CRAT", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7829107" ], "reference_gene_set": "GOBP_FATTY_ACID_BETA_OXIDATION" }, { "gene_set": "IMMPRINT_FATTY_ACID_OXIDATION", "gene_symbol": "SLC25A20", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9399886" ], "reference_gene_set": "REACTOME_FATTY_ACID_METABOLISM" }, { "gene_set": "IMMPRINT_FATTY_ACID_OXIDATION", "gene_symbol": "SLC22A5", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9685390" ], "reference_gene_set": "REACTOME_FATTY_ACID_METABOLISM" }, { "gene_set": "IMMPRINT_FATTY_ACID_OXIDATION", "gene_symbol": "ACADM", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "3035565" ], "reference_gene_set": "REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION" }, { "gene_set": "IMMPRINT_FATTY_ACID_OXIDATION", "gene_symbol": "ACADL", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1774065" ], "reference_gene_set": "REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION" }, { "gene_set": "IMMPRINT_FATTY_ACID_OXIDATION", "gene_symbol": "ACADVL", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7668252" ], "reference_gene_set": "REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION" }, { "gene_set": "IMMPRINT_FATTY_ACID_OXIDATION", "gene_symbol": "ACADS", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2565344" ], "reference_gene_set": "REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION" }, { "gene_set": "IMMPRINT_FATTY_ACID_OXIDATION", "gene_symbol": "HADHA", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8135828" ], "reference_gene_set": "REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION" }, { "gene_set": "IMMPRINT_FATTY_ACID_OXIDATION", "gene_symbol": "HADHB", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8135828" ], "reference_gene_set": "REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION" }, { "gene_set": "IMMPRINT_FATTY_ACID_OXIDATION", "gene_symbol": "HADH", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8687463" ], "reference_gene_set": "REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION" }, { "gene_set": "IMMPRINT_FATTY_ACID_OXIDATION", "gene_symbol": "ECHS1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9073515" ], "reference_gene_set": "REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION" }, { "gene_set": "IMMPRINT_FATTY_ACID_OXIDATION", "gene_symbol": "ACAA2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8241273" ], "reference_gene_set": "REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION" }, { "gene_set": "IMMPRINT_FATTY_ACID_OXIDATION", "gene_symbol": "ETFA", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "3170610" ], "reference_gene_set": "GOBP_FATTY_ACID_BETA_OXIDATION" }, { "gene_set": "IMMPRINT_FATTY_ACID_OXIDATION", "gene_symbol": "ETFB", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8504797" ], "reference_gene_set": "GOBP_FATTY_ACID_BETA_OXIDATION" }, { "gene_set": "IMMPRINT_FATTY_ACID_OXIDATION", "gene_symbol": "PPARA", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "10377439" ], "reference_gene_set": "GOBP_FATTY_ACID_BETA_OXIDATION" }, { "gene_set": "IMMPRINT_GLYCOLYSIS", "gene_symbol": "SLC2A1", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "3839598" ], "reference_gene_set": "GOBP_MONOSACCHARIDE_METABOLIC_PROCESS" }, { "gene_set": "IMMPRINT_GLYCOLYSIS", "gene_symbol": "SLC2A3", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "3170580" ], "reference_gene_set": "GOBP_MONOSACCHARIDE_METABOLIC_PROCESS" }, { "gene_set": "IMMPRINT_GLYCOLYSIS", "gene_symbol": "HK1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "3207429" ], "reference_gene_set": "GOBP_PYRUVATE_METABOLIC_PROCESS" }, { "gene_set": "IMMPRINT_GLYCOLYSIS", "gene_symbol": "HK2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8250948" ], "reference_gene_set": "HALLMARK_GLYCOLYSIS" }, { "gene_set": "IMMPRINT_GLYCOLYSIS", "gene_symbol": "GPI", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8575767" ], "reference_gene_set": "GOBP_PYRUVATE_METABOLIC_PROCESS" }, { "gene_set": "IMMPRINT_GLYCOLYSIS", "gene_symbol": "PFKL", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2533063" ], "reference_gene_set": "GOBP_PYRUVATE_METABOLIC_PROCESS" }, { "gene_set": "IMMPRINT_GLYCOLYSIS", "gene_symbol": "PFKM", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2822475" ], "reference_gene_set": "GOBP_PYRUVATE_METABOLIC_PROCESS" }, { "gene_set": "IMMPRINT_GLYCOLYSIS", "gene_symbol": "PFKP", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8117307" ], "reference_gene_set": "HALLMARK_GLYCOLYSIS" }, { "gene_set": "IMMPRINT_GLYCOLYSIS", "gene_symbol": "ALDOA", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "3840020" ], "reference_gene_set": "HALLMARK_GLYCOLYSIS" }, { "gene_set": "IMMPRINT_GLYCOLYSIS", "gene_symbol": "PGK1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "6188151" ], "reference_gene_set": "HALLMARK_GLYCOLYSIS" }, { "gene_set": "IMMPRINT_GLYCOLYSIS", "gene_symbol": "PGAM1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2846553" ], "reference_gene_set": "HALLMARK_GLYCOLYSIS" }, { "gene_set": "IMMPRINT_GLYCOLYSIS", "gene_symbol": "ENO1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "3529090" ], "reference_gene_set": "HALLMARK_GLYCOLYSIS" }, { "gene_set": "IMMPRINT_GLYCOLYSIS", "gene_symbol": "PKM", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2854097" ], "reference_gene_set": "HALLMARK_GLYCOLYSIS" }, { "gene_set": "IMMPRINT_GLYCOLYSIS", "gene_symbol": "LDHA", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "3838278" ], "reference_gene_set": "HALLMARK_GLYCOLYSIS" }, { "gene_set": "IMMPRINT_GLYCOLYSIS", "gene_symbol": "LDHB", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2930497" ], "reference_gene_set": "GOBP_PYRUVATE_METABOLIC_PROCESS" }, { "gene_set": "IMMPRINT_GLYCOLYSIS", "gene_symbol": "SLC16A1", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "36104287" ], "reference_gene_set": "GOBP_PYRUVATE_METABOLIC_PROCESS" }, { "gene_set": "IMMPRINT_GLYCOLYSIS", "gene_symbol": "SLC16A3", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "36104287" ], "reference_gene_set": "HALLMARK_GLYCOLYSIS" }, { "gene_set": "IMMPRINT_GLYCOLYSIS", "gene_symbol": "PDK1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7499431" ], "reference_gene_set": "GOBP_PYRUVATE_METABOLIC_PROCESS" }, { "gene_set": "IMMPRINT_GLYCOLYSIS", "gene_symbol": "HIF1A", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8089148" ], "reference_gene_set": "GOBP_PYRUVATE_METABOLIC_PROCESS" }, { "gene_set": "IMMPRINT_IFNA_IFNB_SIGNALLING", "gene_symbol": "IFNAR1", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2153461" ], "reference_gene_set": "REACTOME_INTERFERON_ALPHA_BETA_SIGNALING" }, { "gene_set": "IMMPRINT_IFNA_IFNB_SIGNALLING", "gene_symbol": "IFNAR2", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8181059" ], "reference_gene_set": "REACTOME_INTERFERON_ALPHA_BETA_SIGNALING" }, { "gene_set": "IMMPRINT_IFNA_IFNB_SIGNALLING", "gene_symbol": "JAK1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8232552" ], "reference_gene_set": "REACTOME_INTERFERON_ALPHA_BETA_SIGNALING" }, { "gene_set": "IMMPRINT_IFNA_IFNB_SIGNALLING", "gene_symbol": "TYK2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1386289" ], "reference_gene_set": "REACTOME_INTERFERON_ALPHA_BETA_SIGNALING" }, { "gene_set": "IMMPRINT_IFNA_IFNB_SIGNALLING", "gene_symbol": "STAT1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1496401" ], "reference_gene_set": "REACTOME_INTERFERON_ALPHA_BETA_SIGNALING" }, { "gene_set": "IMMPRINT_IFNA_IFNB_SIGNALLING", "gene_symbol": "STAT2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1502204" ], "reference_gene_set": "REACTOME_INTERFERON_ALPHA_BETA_SIGNALING" }, { "gene_set": "IMMPRINT_IFNA_IFNB_SIGNALLING", "gene_symbol": "IRF9", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1630447" ], "reference_gene_set": "REACTOME_INTERFERON_ALPHA_BETA_SIGNALING" }, { "gene_set": "IMMPRINT_IFNA_IFNB_SIGNALLING", "gene_symbol": "IRF7", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "activating", "cell_type": "pan", "pmids": [ "9315633" ], "reference_gene_set": "REACTOME_INTERFERON_ALPHA_BETA_SIGNALING" }, { "gene_set": "IMMPRINT_IFNA_IFNB_SIGNALLING", "gene_symbol": "ISG15", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "3087979" ], "reference_gene_set": "REACTOME_INTERFERON_ALPHA_BETA_SIGNALING" }, { "gene_set": "IMMPRINT_IFNA_IFNB_SIGNALLING", "gene_symbol": "MX1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2481229" ], "reference_gene_set": "REACTOME_INTERFERON_ALPHA_BETA_SIGNALING" }, { "gene_set": "IMMPRINT_IFNA_IFNB_SIGNALLING", "gene_symbol": "MX2", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2481229" ], "reference_gene_set": "REACTOME_INTERFERON_ALPHA_BETA_SIGNALING" }, { "gene_set": "IMMPRINT_IFNA_IFNB_SIGNALLING", "gene_symbol": "OAS1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2411547" ], "reference_gene_set": "REACTOME_INTERFERON_ALPHA_BETA_SIGNALING" }, { "gene_set": "IMMPRINT_IFNA_IFNB_SIGNALLING", "gene_symbol": "OAS2", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1577824" ], "reference_gene_set": "REACTOME_INTERFERON_ALPHA_BETA_SIGNALING" }, { "gene_set": "IMMPRINT_IFNA_IFNB_SIGNALLING", "gene_symbol": "OASL", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9826176" ], "reference_gene_set": "REACTOME_INTERFERON_ALPHA_BETA_SIGNALING" }, { "gene_set": "IMMPRINT_IFNA_IFNB_SIGNALLING", "gene_symbol": "IFIT1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "3360121" ], "reference_gene_set": "REACTOME_INTERFERON_ALPHA_BETA_SIGNALING" }, { "gene_set": "IMMPRINT_IFNA_IFNB_SIGNALLING", "gene_symbol": "IFIT3", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9391139" ], "reference_gene_set": "REACTOME_INTERFERON_ALPHA_BETA_SIGNALING" }, { "gene_set": "IMMPRINT_IFNA_IFNB_SIGNALLING", "gene_symbol": "RSAD2", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "11752458" ], "reference_gene_set": "REACTOME_INTERFERON_ALPHA_BETA_SIGNALING" }, { "gene_set": "IMMPRINT_IFNA_IFNB_SIGNALLING", "gene_symbol": "USP18", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "inhibitory", "cell_type": "pan", "pmids": [ "11788588" ], "reference_gene_set": "REACTOME_INTERFERON_ALPHA_BETA_SIGNALING" }, { "gene_set": "IMMPRINT_IFNA_IFNB_SIGNALLING", "gene_symbol": "IFI6", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "3359997" ], "reference_gene_set": "REACTOME_INTERFERON_ALPHA_BETA_SIGNALING" }, { "gene_set": "IMMPRINT_IFNA_IFNB_SIGNALLING", "gene_symbol": "ISG20", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "12594219" ], "reference_gene_set": "REACTOME_INTERFERON_ALPHA_BETA_SIGNALING" }, { "gene_set": "IMMPRINT_IFNG_SIGNALLING", "gene_symbol": "IFNGR1", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2971451" ], "reference_gene_set": "REACTOME_INTERFERON_GAMMA_SIGNALING" }, { "gene_set": "IMMPRINT_IFNG_SIGNALLING", "gene_symbol": "IFNGR2", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8124717" ], "reference_gene_set": "REACTOME_INTERFERON_GAMMA_SIGNALING" }, { "gene_set": "IMMPRINT_IFNG_SIGNALLING", "gene_symbol": "JAK1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8232552" ], "reference_gene_set": "REACTOME_INTERFERON_GAMMA_SIGNALING" }, { "gene_set": "IMMPRINT_IFNG_SIGNALLING", "gene_symbol": "JAK2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7901766" ], "reference_gene_set": "REACTOME_INTERFERON_GAMMA_SIGNALING" }, { "gene_set": "IMMPRINT_IFNG_SIGNALLING", "gene_symbol": "STAT1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1281555" ], "reference_gene_set": "REACTOME_INTERFERON_GAMMA_SIGNALING" }, { "gene_set": "IMMPRINT_IFNG_SIGNALLING", "gene_symbol": "IRF1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9202213" ], "reference_gene_set": "REACTOME_INTERFERON_GAMMA_SIGNALING" }, { "gene_set": "IMMPRINT_IFNG_SIGNALLING", "gene_symbol": "SOCS1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "inhibitory", "cell_type": "pan", "pmids": [ "9857039" ], "reference_gene_set": "REACTOME_INTERFERON_GAMMA_SIGNALING" }, { "gene_set": "IMMPRINT_IFNG_SIGNALLING", "gene_symbol": "PTPN11", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "context_dependent", "cell_type": "pan", "pmids": [ "10022928" ], "reference_gene_set": "REACTOME_INTERFERON_GAMMA_SIGNALING" }, { "gene_set": "IMMPRINT_IFNG_SIGNALLING", "gene_symbol": "CIITA", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8016643" ], "reference_gene_set": "REACTOME_INTERFERON_GAMMA_SIGNALING" }, { "gene_set": "IMMPRINT_IFNG_SIGNALLING", "gene_symbol": "IRF8", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2111015" ], "reference_gene_set": "REACTOME_INTERFERON_GAMMA_SIGNALING" }, { "gene_set": "IMMPRINT_IFNG_SIGNALLING", "gene_symbol": "CXCL9", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7595201" ], "reference_gene_set": "HALLMARK_INTERFERON_GAMMA_RESPONSE" }, { "gene_set": "IMMPRINT_IFNG_SIGNALLING", "gene_symbol": "CXCL10", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "3925348" ], "reference_gene_set": "HALLMARK_INTERFERON_GAMMA_RESPONSE" }, { "gene_set": "IMMPRINT_IFNG_SIGNALLING", "gene_symbol": "CXCL11", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9625760" ], "reference_gene_set": "HALLMARK_INTERFERON_GAMMA_RESPONSE" }, { "gene_set": "IMMPRINT_IFNG_SIGNALLING", "gene_symbol": "GBP1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "10970849" ], "reference_gene_set": "REACTOME_INTERFERON_GAMMA_SIGNALING" }, { "gene_set": "IMMPRINT_IFNG_SIGNALLING", "gene_symbol": "GBP2", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8706832" ], "reference_gene_set": "REACTOME_INTERFERON_GAMMA_SIGNALING" }, { "gene_set": "IMMPRINT_IFNG_SIGNALLING", "gene_symbol": "IDO1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8188349" ], "reference_gene_set": "HALLMARK_INTERFERON_GAMMA_RESPONSE" }, { "gene_set": "IMMPRINT_IL10_SIGNALLING", "gene_symbol": "IL10RA", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "19890111" ], "reference_gene_set": "REACTOME_INTERLEUKIN_10_SIGNALING" }, { "gene_set": "IMMPRINT_IL10_SIGNALLING", "gene_symbol": "IL10RB", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "19890111" ], "reference_gene_set": "REACTOME_INTERLEUKIN_10_SIGNALING" }, { "gene_set": "IMMPRINT_IL10_SIGNALLING", "gene_symbol": "JAK1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7543512" ], "reference_gene_set": "REACTOME_INTERLEUKIN_10_SIGNALING" }, { "gene_set": "IMMPRINT_IL10_SIGNALLING", "gene_symbol": "TYK2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7543512" ], "reference_gene_set": "REACTOME_INTERLEUKIN_10_SIGNALING" }, { "gene_set": "IMMPRINT_IL10_SIGNALLING", "gene_symbol": "STAT3", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9463379" ], "reference_gene_set": "REACTOME_INTERLEUKIN_10_SIGNALING" }, { "gene_set": "IMMPRINT_IL10_SIGNALLING", "gene_symbol": "STAT1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7543512" ], "reference_gene_set": "HALLMARK_IL6_JAK_STAT3_SIGNALING" }, { "gene_set": "IMMPRINT_IL10_SIGNALLING", "gene_symbol": "SOCS3", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "inhibitory", "cell_type": "pan", "pmids": [ "10515892" ], "reference_gene_set": "HALLMARK_IL6_JAK_STAT3_SIGNALING" }, { "gene_set": "IMMPRINT_IL10_SIGNALLING", "gene_symbol": "BCL3", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "context_dependent", "cell_type": "pan", "pmids": [ "12907458" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL10_SIGNALLING", "gene_symbol": "HMOX1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "11875494" ], "reference_gene_set": "HALLMARK_IL6_JAK_STAT3_SIGNALING" }, { "gene_set": "IMMPRINT_IL10_SIGNALLING", "gene_symbol": "TNIP3", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "17485448", "18081698" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL10_SIGNALLING", "gene_symbol": "IL1RN", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8163946" ], "reference_gene_set": "REACTOME_INTERLEUKIN_10_SIGNALING" }, { "gene_set": "IMMPRINT_IL12_SIGNALLING", "gene_symbol": "IL12RB1", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7911493" ], "reference_gene_set": "REACTOME_INTERLEUKIN_12_SIGNALING" }, { "gene_set": "IMMPRINT_IL12_SIGNALLING", "gene_symbol": "IL12RB2", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8943050" ], "reference_gene_set": "REACTOME_INTERLEUKIN_12_SIGNALING" }, { "gene_set": "IMMPRINT_IL12_SIGNALLING", "gene_symbol": "JAK2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7528775" ], "reference_gene_set": "REACTOME_INTERLEUKIN_12_SIGNALING" }, { "gene_set": "IMMPRINT_IL12_SIGNALLING", "gene_symbol": "TYK2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7528775" ], "reference_gene_set": "REACTOME_INTERLEUKIN_12_SIGNALING" }, { "gene_set": "IMMPRINT_IL12_SIGNALLING", "gene_symbol": "STAT4", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7638186" ], "reference_gene_set": "REACTOME_INTERLEUKIN_12_SIGNALING" }, { "gene_set": "IMMPRINT_IL12_SIGNALLING", "gene_symbol": "STAT3", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7722452" ], "reference_gene_set": "GOBP_T_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE" }, { "gene_set": "IMMPRINT_IL12_SIGNALLING", "gene_symbol": "TBX21", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "10761931" ], "reference_gene_set": "GOBP_T_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE" }, { "gene_set": "IMMPRINT_IL12_SIGNALLING", "gene_symbol": "IFNG", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1672545" ], "reference_gene_set": "REACTOME_INTERLEUKIN_12_SIGNALING" }, { "gene_set": "IMMPRINT_IL12_SIGNALLING", "gene_symbol": "IL18R1", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "10925275" ], "reference_gene_set": "GOBP_T_CELL_DIFFERENTIATION_INVOLVED_IN_IMMUNE_RESPONSE" }, { "gene_set": "IMMPRINT_IL15_SIGNALLING", "gene_symbol": "IL2RB", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "T cell; NK cell", "pmids": [ "8026467" ], "reference_gene_set": "REACTOME_INTERLEUKIN_15_SIGNALING" }, { "gene_set": "IMMPRINT_IL15_SIGNALLING", "gene_symbol": "IL2RG", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "T cell; NK cell", "pmids": [ "8026467" ], "reference_gene_set": "REACTOME_INTERLEUKIN_15_SIGNALING" }, { "gene_set": "IMMPRINT_IL15_SIGNALLING", "gene_symbol": "JAK1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell; NK cell", "pmids": [ "7568001" ], "reference_gene_set": "REACTOME_INTERLEUKIN_15_SIGNALING" }, { "gene_set": "IMMPRINT_IL15_SIGNALLING", "gene_symbol": "JAK3", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell; NK cell", "pmids": [ "7659163" ], "reference_gene_set": "REACTOME_INTERLEUKIN_15_SIGNALING" }, { "gene_set": "IMMPRINT_IL15_SIGNALLING", "gene_symbol": "STAT5A", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell; NK cell", "pmids": [ "7568001" ], "reference_gene_set": "REACTOME_INTERLEUKIN_15_SIGNALING" }, { "gene_set": "IMMPRINT_IL15_SIGNALLING", "gene_symbol": "STAT5B", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell; NK cell", "pmids": [ "7568001" ], "reference_gene_set": "REACTOME_INTERLEUKIN_15_SIGNALING" }, { "gene_set": "IMMPRINT_IL15_SIGNALLING", "gene_symbol": "BCL2", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "T cell; NK cell", "pmids": [ "8617294" ], "reference_gene_set": "HALLMARK_IL2_STAT5_SIGNALING" }, { "gene_set": "IMMPRINT_IL15_SIGNALLING", "gene_symbol": "MCL1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "T cell; NK cell", "pmids": [ "35351861", "9062351" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL15_SIGNALLING", "gene_symbol": "CISH", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "inhibitory", "cell_type": "T cell; NK cell", "pmids": [ "32531207" ], "reference_gene_set": "HALLMARK_IL2_STAT5_SIGNALING" }, { "gene_set": "IMMPRINT_IL17_SIGNALLING", "gene_symbol": "IL17RA", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "16785495" ], "reference_gene_set": "REACTOME_INTERLEUKIN_17_SIGNALING" }, { "gene_set": "IMMPRINT_IL17_SIGNALLING", "gene_symbol": "IL17RC", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "16785495" ], "reference_gene_set": "REACTOME_INTERLEUKIN_17_SIGNALING" }, { "gene_set": "IMMPRINT_IL17_SIGNALLING", "gene_symbol": "TRAF3IP2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "17035243" ], "reference_gene_set": "GOBP_RESPONSE_TO_TUMOR_NECROSIS_FACTOR" }, { "gene_set": "IMMPRINT_IL17_SIGNALLING", "gene_symbol": "TRAF6", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "10748240" ], "reference_gene_set": "REACTOME_INTERLEUKIN_17_SIGNALING" }, { "gene_set": "IMMPRINT_IL17_SIGNALLING", "gene_symbol": "TRAF2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "21822258" ], "reference_gene_set": "GOBP_RESPONSE_TO_TUMOR_NECROSIS_FACTOR" }, { "gene_set": "IMMPRINT_IL17_SIGNALLING", "gene_symbol": "TRAF5", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "21822258" ], "reference_gene_set": "GOBP_RESPONSE_TO_TUMOR_NECROSIS_FACTOR" }, { "gene_set": "IMMPRINT_IL17_SIGNALLING", "gene_symbol": "NFKBIZ", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "18362142", "35537286" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL17_SIGNALLING", "gene_symbol": "NFKB1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "10228009" ], "reference_gene_set": "REACTOME_INTERLEUKIN_17_SIGNALING" }, { "gene_set": "IMMPRINT_IL17_SIGNALLING", "gene_symbol": "RELA", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "10228009" ], "reference_gene_set": "GOBP_RESPONSE_TO_TUMOR_NECROSIS_FACTOR" }, { "gene_set": "IMMPRINT_IL17_SIGNALLING", "gene_symbol": "CEBPB", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "21085185", "16798734" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL17_SIGNALLING", "gene_symbol": "CXCL8", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8676080", "21085185" ], "reference_gene_set": "" }, { "gene_set": "IMMPRINT_IL17_SIGNALLING", "gene_symbol": "DEFB4A", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "21085185", "15322213", "18684158" ], "reference_gene_set": "" }, { "gene_set": "IMMPRINT_IL17_SIGNALLING", "gene_symbol": "S100A9", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "21085185", "18684158" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL18_SIGNALLING", "gene_symbol": "IL18R1", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9325300" ], "reference_gene_set": "REACTOME_INTERLEUKIN_18_SIGNALING" }, { "gene_set": "IMMPRINT_IL18_SIGNALLING", "gene_symbol": "IL18RAP", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9792649" ], "reference_gene_set": "REACTOME_INTERLEUKIN_18_SIGNALING" }, { "gene_set": "IMMPRINT_IL18_SIGNALLING", "gene_symbol": "MYD88", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9697844" ], "reference_gene_set": "REACTOME_INTERLEUKIN_1_SIGNALING" }, { "gene_set": "IMMPRINT_IL18_SIGNALLING", "gene_symbol": "IRAK1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "10190904" ], "reference_gene_set": "REACTOME_INTERLEUKIN_1_SIGNALING" }, { "gene_set": "IMMPRINT_IL18_SIGNALLING", "gene_symbol": "IRAK4", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "11960013" ], "reference_gene_set": "REACTOME_INTERLEUKIN_1_SIGNALING" }, { "gene_set": "IMMPRINT_IL18_SIGNALLING", "gene_symbol": "TRAF6", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9514903" ], "reference_gene_set": "REACTOME_INTERLEUKIN_1_SIGNALING" }, { "gene_set": "IMMPRINT_IL18_SIGNALLING", "gene_symbol": "NFKB1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "10925275" ], "reference_gene_set": "REACTOME_INTERLEUKIN_1_SIGNALING" }, { "gene_set": "IMMPRINT_IL18_SIGNALLING", "gene_symbol": "RELA", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "10925275" ], "reference_gene_set": "REACTOME_INTERLEUKIN_1_SIGNALING" }, { "gene_set": "IMMPRINT_IL18_SIGNALLING", "gene_symbol": "PRKCD", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "17530707" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL18_SIGNALLING", "gene_symbol": "IFNG", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8766574" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL1_SIGNALLING", "gene_symbol": "IL1R1", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2530587" ], "reference_gene_set": "REACTOME_INTERLEUKIN_1_SIGNALING" }, { "gene_set": "IMMPRINT_IL1_SIGNALLING", "gene_symbol": "IL1RAP", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9371760" ], "reference_gene_set": "REACTOME_INTERLEUKIN_1_SIGNALING" }, { "gene_set": "IMMPRINT_IL1_SIGNALLING", "gene_symbol": "MYD88", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9697844" ], "reference_gene_set": "REACTOME_INTERLEUKIN_1_SIGNALING" }, { "gene_set": "IMMPRINT_IL1_SIGNALLING", "gene_symbol": "IRAK1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8599092" ], "reference_gene_set": "REACTOME_INTERLEUKIN_1_SIGNALING" }, { "gene_set": "IMMPRINT_IL1_SIGNALLING", "gene_symbol": "IRAK4", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "11960013" ], "reference_gene_set": "REACTOME_INTERLEUKIN_1_SIGNALING" }, { "gene_set": "IMMPRINT_IL1_SIGNALLING", "gene_symbol": "TRAF6", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8837778" ], "reference_gene_set": "REACTOME_INTERLEUKIN_1_SIGNALING" }, { "gene_set": "IMMPRINT_IL1_SIGNALLING", "gene_symbol": "NFKB1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2494664" ], "reference_gene_set": "REACTOME_INTERLEUKIN_1_SIGNALING" }, { "gene_set": "IMMPRINT_IL1_SIGNALLING", "gene_symbol": "RELA", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2494664" ], "reference_gene_set": "REACTOME_INTERLEUKIN_1_SIGNALING" }, { "gene_set": "IMMPRINT_IL1_SIGNALLING", "gene_symbol": "CHUK", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9346484" ], "reference_gene_set": "REACTOME_INTERLEUKIN_1_SIGNALING" }, { "gene_set": "IMMPRINT_IL1_SIGNALLING", "gene_symbol": "IKBKB", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9346241" ], "reference_gene_set": "REACTOME_INTERLEUKIN_1_SIGNALING" }, { "gene_set": "IMMPRINT_IL1_SIGNALLING", "gene_symbol": "IKBKG", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9751060" ], "reference_gene_set": "REACTOME_INTERLEUKIN_1_SIGNALING" }, { "gene_set": "IMMPRINT_IL1_SIGNALLING", "gene_symbol": "PTGS2", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1694171", "8132748" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL21_SIGNALLING", "gene_symbol": "IL21R", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "11081504" ], "reference_gene_set": "REACTOME_INTERLEUKIN_21_SIGNALING" }, { "gene_set": "IMMPRINT_IL21_SIGNALLING", "gene_symbol": "IL2RG", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "11418623" ], "reference_gene_set": "REACTOME_INTERLEUKIN_21_SIGNALING" }, { "gene_set": "IMMPRINT_IL21_SIGNALLING", "gene_symbol": "JAK1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "11418623" ], "reference_gene_set": "REACTOME_INTERLEUKIN_21_SIGNALING" }, { "gene_set": "IMMPRINT_IL21_SIGNALLING", "gene_symbol": "JAK3", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7659163" ], "reference_gene_set": "REACTOME_INTERLEUKIN_21_SIGNALING" }, { "gene_set": "IMMPRINT_IL21_SIGNALLING", "gene_symbol": "STAT3", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "25398835" ], "reference_gene_set": "REACTOME_INTERLEUKIN_21_SIGNALING" }, { "gene_set": "IMMPRINT_IL21_SIGNALLING", "gene_symbol": "STAT1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "25398835" ], "reference_gene_set": "REACTOME_INTERLEUKIN_21_SIGNALING" }, { "gene_set": "IMMPRINT_IL21_SIGNALLING", "gene_symbol": "STAT5A", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "25398835" ], "reference_gene_set": "REACTOME_INTERLEUKIN_21_SIGNALING" }, { "gene_set": "IMMPRINT_IL21_SIGNALLING", "gene_symbol": "STAT5B", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "25398835" ], "reference_gene_set": "REACTOME_INTERLEUKIN_21_SIGNALING" }, { "gene_set": "IMMPRINT_IL21_SIGNALLING", "gene_symbol": "PRDM1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "15494482" ], "reference_gene_set": "GOBP_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION" }, { "gene_set": "IMMPRINT_IL21_SIGNALLING", "gene_symbol": "BCL6", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "15494482" ], "reference_gene_set": "GOBP_REGULATION_OF_LYMPHOCYTE_DIFFERENTIATION" }, { "gene_set": "IMMPRINT_IL23_SIGNALLING", "gene_symbol": "IL23R", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "12023369" ], "reference_gene_set": "REACTOME_INTERLEUKIN_23_SIGNALING" }, { "gene_set": "IMMPRINT_IL23_SIGNALLING", "gene_symbol": "IL12RB1", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "12023369" ], "reference_gene_set": "REACTOME_INTERLEUKIN_23_SIGNALING" }, { "gene_set": "IMMPRINT_IL23_SIGNALLING", "gene_symbol": "JAK2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "12023369" ], "reference_gene_set": "REACTOME_INTERLEUKIN_23_SIGNALING" }, { "gene_set": "IMMPRINT_IL23_SIGNALLING", "gene_symbol": "TYK2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "12023369" ], "reference_gene_set": "REACTOME_INTERLEUKIN_23_SIGNALING" }, { "gene_set": "IMMPRINT_IL23_SIGNALLING", "gene_symbol": "STAT3", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "12023369" ], "reference_gene_set": "REACTOME_INTERLEUKIN_23_SIGNALING" }, { "gene_set": "IMMPRINT_IL23_SIGNALLING", "gene_symbol": "STAT4", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "12023369" ], "reference_gene_set": "REACTOME_INTERLEUKIN_23_SIGNALING" }, { "gene_set": "IMMPRINT_IL23_SIGNALLING", "gene_symbol": "RORC", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "18454151" ], "reference_gene_set": "GOBP_T_HELPER_17_TYPE_IMMUNE_RESPONSE" }, { "gene_set": "IMMPRINT_IL23_SIGNALLING", "gene_symbol": "RORA", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "18164222" ], "reference_gene_set": "GOBP_T_HELPER_17_TYPE_IMMUNE_RESPONSE" }, { "gene_set": "IMMPRINT_IL23_SIGNALLING", "gene_symbol": "AHR", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "18362914", "19114668" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL23_SIGNALLING", "gene_symbol": "BATF", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "19578362" ], "reference_gene_set": "GOBP_T_HELPER_17_TYPE_IMMUNE_RESPONSE" }, { "gene_set": "IMMPRINT_IL23_SIGNALLING", "gene_symbol": "IL17A", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "17676044" ], "reference_gene_set": "GOBP_T_HELPER_17_TYPE_IMMUNE_RESPONSE" }, { "gene_set": "IMMPRINT_IL23_SIGNALLING", "gene_symbol": "IL17F", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "17676044" ], "reference_gene_set": "GOBP_T_HELPER_17_TYPE_IMMUNE_RESPONSE" }, { "gene_set": "IMMPRINT_IL23_SIGNALLING", "gene_symbol": "IL22", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "17676044", "18978771" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL2_SIGNALLING", "gene_symbol": "IL2RA", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "6090948" ], "reference_gene_set": "REACTOME_INTERLEUKIN_2_SIGNALING" }, { "gene_set": "IMMPRINT_IL2_SIGNALLING", "gene_symbol": "IL2RB", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2785715" ], "reference_gene_set": "REACTOME_INTERLEUKIN_2_SIGNALING" }, { "gene_set": "IMMPRINT_IL2_SIGNALLING", "gene_symbol": "IL2RG", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1631559" ], "reference_gene_set": "REACTOME_INTERLEUKIN_2_SIGNALING" }, { "gene_set": "IMMPRINT_IL2_SIGNALLING", "gene_symbol": "JAK1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7973659" ], "reference_gene_set": "REACTOME_INTERLEUKIN_2_SIGNALING" }, { "gene_set": "IMMPRINT_IL2_SIGNALLING", "gene_symbol": "JAK3", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7659163" ], "reference_gene_set": "REACTOME_INTERLEUKIN_2_SIGNALING" }, { "gene_set": "IMMPRINT_IL2_SIGNALLING", "gene_symbol": "STAT5A", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7719938" ], "reference_gene_set": "REACTOME_INTERLEUKIN_2_SIGNALING" }, { "gene_set": "IMMPRINT_IL2_SIGNALLING", "gene_symbol": "STAT5B", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7719938" ], "reference_gene_set": "REACTOME_INTERLEUKIN_2_SIGNALING" }, { "gene_set": "IMMPRINT_IL2_SIGNALLING", "gene_symbol": "PIK3R1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1713578" ], "reference_gene_set": "REACTOME_REGULATION_OF_T_CELL_ACTIVATION_BY_CD28_FAMILY" }, { "gene_set": "IMMPRINT_IL2_SIGNALLING", "gene_symbol": "AKT1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9390691" ], "reference_gene_set": "REACTOME_REGULATION_OF_T_CELL_ACTIVATION_BY_CD28_FAMILY" }, { "gene_set": "IMMPRINT_IL2_SIGNALLING", "gene_symbol": "MTOR", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "10373522" ], "reference_gene_set": "REACTOME_REGULATION_OF_T_CELL_ACTIVATION_BY_CD28_FAMILY" }, { "gene_set": "IMMPRINT_IL2_SIGNALLING", "gene_symbol": "CISH", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "inhibitory", "cell_type": "pan", "pmids": [ "10514520" ], "reference_gene_set": "HALLMARK_IL2_STAT5_SIGNALING" }, { "gene_set": "IMMPRINT_IL2_SIGNALLING", "gene_symbol": "SOCS3", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "inhibitory", "cell_type": "pan", "pmids": [ "10373548", "16199887" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL2_SIGNALLING", "gene_symbol": "BCL2", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8617294" ], "reference_gene_set": "HALLMARK_IL2_STAT5_SIGNALING" }, { "gene_set": "IMMPRINT_IL4_IL13_SIGNALLING", "gene_symbol": "IL4R", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2307934" ], "reference_gene_set": "REACTOME_INTERLEUKIN_4_AND_INTERLEUKIN_13_SIGNALING" }, { "gene_set": "IMMPRINT_IL4_IL13_SIGNALLING", "gene_symbol": "IL13RA1", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8910586" ], "reference_gene_set": "REACTOME_INTERLEUKIN_4_AND_INTERLEUKIN_13_SIGNALING" }, { "gene_set": "IMMPRINT_IL4_IL13_SIGNALLING", "gene_symbol": "IL13RA2", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "inhibitory", "cell_type": "pan", "pmids": [ "8663118" ], "reference_gene_set": "REACTOME_INTERLEUKIN_4_AND_INTERLEUKIN_13_SIGNALING" }, { "gene_set": "IMMPRINT_IL4_IL13_SIGNALLING", "gene_symbol": "IL2RG", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8266078" ], "reference_gene_set": "REACTOME_INTERLEUKIN_4_AND_INTERLEUKIN_13_SIGNALING" }, { "gene_set": "IMMPRINT_IL4_IL13_SIGNALLING", "gene_symbol": "JAK1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9045682" ], "reference_gene_set": "REACTOME_INTERLEUKIN_4_AND_INTERLEUKIN_13_SIGNALING" }, { "gene_set": "IMMPRINT_IL4_IL13_SIGNALLING", "gene_symbol": "JAK2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9822675" ], "reference_gene_set": "REACTOME_INTERLEUKIN_4_AND_INTERLEUKIN_13_SIGNALING" }, { "gene_set": "IMMPRINT_IL4_IL13_SIGNALLING", "gene_symbol": "JAK3", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7659163" ], "reference_gene_set": "REACTOME_INTERLEUKIN_4_AND_INTERLEUKIN_13_SIGNALING" }, { "gene_set": "IMMPRINT_IL4_IL13_SIGNALLING", "gene_symbol": "TYK2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9822675" ], "reference_gene_set": "REACTOME_INTERLEUKIN_4_AND_INTERLEUKIN_13_SIGNALING" }, { "gene_set": "IMMPRINT_IL4_IL13_SIGNALLING", "gene_symbol": "STAT6", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8085155" ], "reference_gene_set": "REACTOME_INTERLEUKIN_4_AND_INTERLEUKIN_13_SIGNALING" }, { "gene_set": "IMMPRINT_IL4_IL13_SIGNALLING", "gene_symbol": "IRS2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7499365", "7675087" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL4_IL13_SIGNALLING", "gene_symbol": "SOCS1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "inhibitory", "cell_type": "pan", "pmids": [ "10201892" ], "reference_gene_set": "REACTOME_INTERLEUKIN_4_AND_INTERLEUKIN_13_SIGNALING" }, { "gene_set": "IMMPRINT_IL4_IL13_SIGNALLING", "gene_symbol": "CCL26", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Epithelial; Fibroblast; Endothelial", "pmids": [ "11544308", "16084752" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL4_IL13_SIGNALLING", "gene_symbol": "CCL22", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9794440" ], "reference_gene_set": "REACTOME_INTERLEUKIN_4_AND_INTERLEUKIN_13_SIGNALING" }, { "gene_set": "IMMPRINT_IL6_SIGNALLING", "gene_symbol": "IL6R", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "3136546" ], "reference_gene_set": "REACTOME_INTERLEUKIN_6_SIGNALING" }, { "gene_set": "IMMPRINT_IL6_SIGNALLING", "gene_symbol": "IL6ST", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2261637" ], "reference_gene_set": "REACTOME_INTERLEUKIN_6_SIGNALING" }, { "gene_set": "IMMPRINT_IL6_SIGNALLING", "gene_symbol": "JAK1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8272872" ], "reference_gene_set": "REACTOME_INTERLEUKIN_6_SIGNALING" }, { "gene_set": "IMMPRINT_IL6_SIGNALLING", "gene_symbol": "JAK2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8272873" ], "reference_gene_set": "REACTOME_INTERLEUKIN_6_SIGNALING" }, { "gene_set": "IMMPRINT_IL6_SIGNALLING", "gene_symbol": "TYK2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8272873" ], "reference_gene_set": "REACTOME_INTERLEUKIN_6_SIGNALING" }, { "gene_set": "IMMPRINT_IL6_SIGNALLING", "gene_symbol": "STAT3", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8140422" ], "reference_gene_set": "REACTOME_INTERLEUKIN_6_SIGNALING" }, { "gene_set": "IMMPRINT_IL6_SIGNALLING", "gene_symbol": "STAT1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "11104703" ], "reference_gene_set": "REACTOME_INTERLEUKIN_6_SIGNALING" }, { "gene_set": "IMMPRINT_IL6_SIGNALLING", "gene_symbol": "SOCS3", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "inhibitory", "cell_type": "pan", "pmids": [ "12754505" ], "reference_gene_set": "REACTOME_INTERLEUKIN_6_SIGNALING" }, { "gene_set": "IMMPRINT_IL6_SIGNALLING", "gene_symbol": "PTPN11", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "context_dependent", "cell_type": "pan", "pmids": [ "10777583" ], "reference_gene_set": "REACTOME_INTERLEUKIN_6_SIGNALING" }, { "gene_set": "IMMPRINT_IL6_SIGNALLING", "gene_symbol": "MCL1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "10602002", "11175262" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL6_SIGNALLING", "gene_symbol": "CRP", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2472097" ], "reference_gene_set": "GOBP_ACUTE_PHASE_RESPONSE" }, { "gene_set": "IMMPRINT_IL6_SIGNALLING", "gene_symbol": "SAA1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2472097" ], "reference_gene_set": "GOBP_ACUTE_PHASE_RESPONSE" }, { "gene_set": "IMMPRINT_IL6_SIGNALLING", "gene_symbol": "FGB", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2472097", "8423785" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL7_SIGNALLING", "gene_symbol": "IL7R", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "2317865" ], "reference_gene_set": "REACTOME_INTERLEUKIN_7_SIGNALING" }, { "gene_set": "IMMPRINT_IL7_SIGNALLING", "gene_symbol": "IL2RG", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "8462096" ], "reference_gene_set": "REACTOME_INTERLEUKIN_7_SIGNALING" }, { "gene_set": "IMMPRINT_IL7_SIGNALLING", "gene_symbol": "JAK1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "7489741" ], "reference_gene_set": "REACTOME_INTERLEUKIN_7_SIGNALING" }, { "gene_set": "IMMPRINT_IL7_SIGNALLING", "gene_symbol": "JAK3", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "7659163" ], "reference_gene_set": "REACTOME_INTERLEUKIN_7_SIGNALING" }, { "gene_set": "IMMPRINT_IL7_SIGNALLING", "gene_symbol": "STAT5A", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "7489741" ], "reference_gene_set": "REACTOME_INTERLEUKIN_7_SIGNALING" }, { "gene_set": "IMMPRINT_IL7_SIGNALLING", "gene_symbol": "STAT5B", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "7489741" ], "reference_gene_set": "REACTOME_INTERLEUKIN_7_SIGNALING" }, { "gene_set": "IMMPRINT_IL7_SIGNALLING", "gene_symbol": "PIK3R1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "8397227" ], "reference_gene_set": "REACTOME_INTERLEUKIN_7_SIGNALING" }, { "gene_set": "IMMPRINT_IL7_SIGNALLING", "gene_symbol": "AKT1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "18523275" ], "reference_gene_set": "REACTOME_ACTIVATION_OF_BAD_AND_TRANSLOCATION_TO_MITOCHONDRIA" }, { "gene_set": "IMMPRINT_IL7_SIGNALLING", "gene_symbol": "BCL2", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "20465565" ], "reference_gene_set": "REACTOME_ACTIVATION_OF_BAD_AND_TRANSLOCATION_TO_MITOCHONDRIA" }, { "gene_set": "IMMPRINT_IL7_SIGNALLING", "gene_symbol": "MCL1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "20465565" ], "reference_gene_set": "" }, { "gene_set": "IMMPRINT_MHC_CLASS_I", "gene_symbol": "HLA-A", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "3309677" ], "reference_gene_set": "REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC" }, { "gene_set": "IMMPRINT_MHC_CLASS_I", "gene_symbol": "HLA-B", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1922337" ], "reference_gene_set": "REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC" }, { "gene_set": "IMMPRINT_MHC_CLASS_I", "gene_symbol": "HLA-C", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "6609813" ], "reference_gene_set": "REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC" }, { "gene_set": "IMMPRINT_MHC_CLASS_I", "gene_symbol": "HLA-E", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "3260916" ], "reference_gene_set": "REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC" }, { "gene_set": "IMMPRINT_MHC_CLASS_I", "gene_symbol": "HLA-F", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1688605" ], "reference_gene_set": "REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC" }, { "gene_set": "IMMPRINT_MHC_CLASS_I", "gene_symbol": "HLA-G", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "3480534" ], "reference_gene_set": "REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC" }, { "gene_set": "IMMPRINT_MHC_CLASS_I", "gene_symbol": "B2M", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "25702838" ], "reference_gene_set": "REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC" }, { "gene_set": "IMMPRINT_MHC_CLASS_I", "gene_symbol": "TAP1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2259384" ], "reference_gene_set": "REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC" }, { "gene_set": "IMMPRINT_MHC_CLASS_I", "gene_symbol": "TAP2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1538751" ], "reference_gene_set": "REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC" }, { "gene_set": "IMMPRINT_MHC_CLASS_I", "gene_symbol": "TAPBP", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8769474" ], "reference_gene_set": "REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC" }, { "gene_set": "IMMPRINT_MHC_CLASS_I", "gene_symbol": "CALR", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8769474" ], "reference_gene_set": "REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC" }, { "gene_set": "IMMPRINT_MHC_CLASS_I", "gene_symbol": "CANX", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8278813" ], "reference_gene_set": "REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC" }, { "gene_set": "IMMPRINT_MHC_CLASS_I", "gene_symbol": "PDIA3", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9637923" ], "reference_gene_set": "REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC" }, { "gene_set": "IMMPRINT_MHC_CLASS_I", "gene_symbol": "PSMB8", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "21881205" ], "reference_gene_set": "HALLMARK_INTERFERON_GAMMA_RESPONSE" }, { "gene_set": "IMMPRINT_MHC_CLASS_I", "gene_symbol": "PSMB9", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1922342" ], "reference_gene_set": "HALLMARK_INTERFERON_GAMMA_RESPONSE" }, { "gene_set": "IMMPRINT_MHC_CLASS_I", "gene_symbol": "PSMB10", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8786291" ], "reference_gene_set": "HALLMARK_INTERFERON_GAMMA_RESPONSE" }, { "gene_set": "IMMPRINT_MHC_CLASS_I", "gene_symbol": "ERAP1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "12436109" ], "reference_gene_set": "REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC" }, { "gene_set": "IMMPRINT_MHC_CLASS_I", "gene_symbol": "NLRC5", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "20639463" ], "reference_gene_set": "HALLMARK_INTERFERON_GAMMA_RESPONSE" }, { "gene_set": "IMMPRINT_MHC_CLASS_II", "gene_symbol": "HLA-DRA", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8316295" ], "reference_gene_set": "REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION" }, { "gene_set": "IMMPRINT_MHC_CLASS_II", "gene_symbol": "HLA-DRB1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8316295" ], "reference_gene_set": "REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION" }, { "gene_set": "IMMPRINT_MHC_CLASS_II", "gene_symbol": "HLA-DQA1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "15020763" ], "reference_gene_set": "REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION" }, { "gene_set": "IMMPRINT_MHC_CLASS_II", "gene_symbol": "HLA-DQB1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "15020763" ], "reference_gene_set": "REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION" }, { "gene_set": "IMMPRINT_MHC_CLASS_II", "gene_symbol": "HLA-DPA1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "20356827" ], "reference_gene_set": "REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION" }, { "gene_set": "IMMPRINT_MHC_CLASS_II", "gene_symbol": "HLA-DPB1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "20356827" ], "reference_gene_set": "REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION" }, { "gene_set": "IMMPRINT_MHC_CLASS_II", "gene_symbol": "HLA-DMA", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8139690" ], "reference_gene_set": "REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION" }, { "gene_set": "IMMPRINT_MHC_CLASS_II", "gene_symbol": "HLA-DMB", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8139690" ], "reference_gene_set": "REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION" }, { "gene_set": "IMMPRINT_MHC_CLASS_II", "gene_symbol": "HLA-DOA", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9311912" ], "reference_gene_set": "REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION" }, { "gene_set": "IMMPRINT_MHC_CLASS_II", "gene_symbol": "HLA-DOB", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9311912" ], "reference_gene_set": "REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION" }, { "gene_set": "IMMPRINT_MHC_CLASS_II", "gene_symbol": "CD74", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "376435" ], "reference_gene_set": "REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION" }, { "gene_set": "IMMPRINT_MHC_CLASS_II", "gene_symbol": "CIITA", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8402893" ], "reference_gene_set": "GOBP_MHC_CLASS_II_BIOSYNTHETIC_PROCESS" }, { "gene_set": "IMMPRINT_MHC_CLASS_II", "gene_symbol": "RFX5", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7744245" ], "reference_gene_set": "GOBP_MHC_CLASS_II_BIOSYNTHETIC_PROCESS" }, { "gene_set": "IMMPRINT_MHC_CLASS_II", "gene_symbol": "RFXAP", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9118943" ], "reference_gene_set": "GOBP_MHC_CLASS_II_BIOSYNTHETIC_PROCESS" }, { "gene_set": "IMMPRINT_MHC_CLASS_II", "gene_symbol": "RFXANK", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9806546" ], "reference_gene_set": "GOBP_MHC_CLASS_II_BIOSYNTHETIC_PROCESS" }, { "gene_set": "IMMPRINT_NLRP3_INFLAMMASOME", "gene_symbol": "NLRP3", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "11687797" ], "reference_gene_set": "REACTOME_THE_NLRP3_INFLAMMASOME" }, { "gene_set": "IMMPRINT_NLRP3_INFLAMMASOME", "gene_symbol": "PYCARD", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "11967258" ], "reference_gene_set": "REACTOME_THE_NLRP3_INFLAMMASOME" }, { "gene_set": "IMMPRINT_NLRP3_INFLAMMASOME", "gene_symbol": "CASP1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1574116" ], "reference_gene_set": "REACTOME_THE_NLRP3_INFLAMMASOME" }, { "gene_set": "IMMPRINT_NLRP3_INFLAMMASOME", "gene_symbol": "CASP4", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "25119034" ], "reference_gene_set": "REACTOME_PYROPTOSIS" }, { "gene_set": "IMMPRINT_NLRP3_INFLAMMASOME", "gene_symbol": "CASP5", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "25119034" ], "reference_gene_set": "REACTOME_PYROPTOSIS" }, { "gene_set": "IMMPRINT_NLRP3_INFLAMMASOME", "gene_symbol": "NEK7", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "26814970", "26553871" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_NLRP3_INFLAMMASOME", "gene_symbol": "GSDMD", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "26375003" ], "reference_gene_set": "REACTOME_PYROPTOSIS" }, { "gene_set": "IMMPRINT_NLRP3_INFLAMMASOME", "gene_symbol": "IL1B", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1373520" ], "reference_gene_set": "REACTOME_PYROPTOSIS" }, { "gene_set": "IMMPRINT_NLRP3_INFLAMMASOME", "gene_symbol": "IL18", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9121587" ], "reference_gene_set": "REACTOME_PYROPTOSIS" }, { "gene_set": "IMMPRINT_NLRP3_INFLAMMASOME", "gene_symbol": "TXNIP", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "20023662" ], "reference_gene_set": "REACTOME_THE_NLRP3_INFLAMMASOME" }, { "gene_set": "IMMPRINT_NLRP3_INFLAMMASOME", "gene_symbol": "P2RX7", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "16547218" ], "reference_gene_set": "REACTOME_THE_NLRP3_INFLAMMASOME" }, { "gene_set": "IMMPRINT_NOD_SIGNALLING", "gene_symbol": "NOD1", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "10329646" ], "reference_gene_set": "REACTOME_NOD1_2_SIGNALING_PATHWAY" }, { "gene_set": "IMMPRINT_NOD_SIGNALLING", "gene_symbol": "NOD2", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "11385576" ], "reference_gene_set": "REACTOME_NOD1_2_SIGNALING_PATHWAY" }, { "gene_set": "IMMPRINT_NOD_SIGNALLING", "gene_symbol": "RIPK2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "11894098" ], "reference_gene_set": "REACTOME_NOD1_2_SIGNALING_PATHWAY" }, { "gene_set": "IMMPRINT_NOD_SIGNALLING", "gene_symbol": "NFKB1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2203532" ], "reference_gene_set": "GOBP_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY" }, { "gene_set": "IMMPRINT_NOD_SIGNALLING", "gene_symbol": "RELA", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2001591" ], "reference_gene_set": "GOBP_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY" }, { "gene_set": "IMMPRINT_NOD_SIGNALLING", "gene_symbol": "CHUK", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9252186" ], "reference_gene_set": "REACTOME_NOD1_2_SIGNALING_PATHWAY" }, { "gene_set": "IMMPRINT_NOD_SIGNALLING", "gene_symbol": "IKBKB", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9346485" ], "reference_gene_set": "REACTOME_NOD1_2_SIGNALING_PATHWAY" }, { "gene_set": "IMMPRINT_NOD_SIGNALLING", "gene_symbol": "IKBKG", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9657155" ], "reference_gene_set": "REACTOME_NOD1_2_SIGNALING_PATHWAY" }, { "gene_set": "IMMPRINT_NOD_SIGNALLING", "gene_symbol": "XIAP", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "19667203" ], "reference_gene_set": "GOBP_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY" }, { "gene_set": "IMMPRINT_NOD_SIGNALLING", "gene_symbol": "BIRC2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "19464198" ], "reference_gene_set": "REACTOME_NOD1_2_SIGNALING_PATHWAY" }, { "gene_set": "IMMPRINT_NOD_SIGNALLING", "gene_symbol": "BIRC3", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "19464198" ], "reference_gene_set": "REACTOME_NOD1_2_SIGNALING_PATHWAY" }, { "gene_set": "IMMPRINT_NOD_SIGNALLING", "gene_symbol": "CXCL8", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "15617523" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_NOD_SIGNALLING", "gene_symbol": "CCL2", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "22590599" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_NOD_SIGNALLING", "gene_symbol": "DEFB4A", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "16319062" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_NOD_SIGNALLING", "gene_symbol": "IL6", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "16414084" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_NOTCH_SIGNALLING", "gene_symbol": "NOTCH1", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1831692" ], "reference_gene_set": "REACTOME_SIGNALING_BY_NOTCH" }, { "gene_set": "IMMPRINT_NOTCH_SIGNALLING", "gene_symbol": "NOTCH2", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "16773578" ], "reference_gene_set": "REACTOME_SIGNALING_BY_NOTCH" }, { "gene_set": "IMMPRINT_NOTCH_SIGNALLING", "gene_symbol": "NOTCH3", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8878478" ], "reference_gene_set": "REACTOME_SIGNALING_BY_NOTCH" }, { "gene_set": "IMMPRINT_NOTCH_SIGNALLING", "gene_symbol": "NOTCH4", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8681805" ], "reference_gene_set": "REACTOME_SIGNALING_BY_NOTCH" }, { "gene_set": "IMMPRINT_NOTCH_SIGNALLING", "gene_symbol": "RBPJ", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8749394" ], "reference_gene_set": "REACTOME_SIGNALING_BY_NOTCH" }, { "gene_set": "IMMPRINT_NOTCH_SIGNALLING", "gene_symbol": "HES1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7566092" ], "reference_gene_set": "REACTOME_SIGNALING_BY_NOTCH" }, { "gene_set": "IMMPRINT_NOTCH_SIGNALLING", "gene_symbol": "HES5", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "10205173" ], "reference_gene_set": "REACTOME_SIGNALING_BY_NOTCH" }, { "gene_set": "IMMPRINT_NOTCH_SIGNALLING", "gene_symbol": "HEY1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "11095750" ], "reference_gene_set": "REACTOME_SIGNALING_BY_NOTCH" }, { "gene_set": "IMMPRINT_NOTCH_SIGNALLING", "gene_symbol": "HEY2", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "11095750" ], "reference_gene_set": "REACTOME_SIGNALING_BY_NOTCH" }, { "gene_set": "IMMPRINT_NOTCH_SIGNALLING", "gene_symbol": "MAML1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "11101851" ], "reference_gene_set": "REACTOME_SIGNALING_BY_NOTCH" }, { "gene_set": "IMMPRINT_NOTCH_SIGNALLING", "gene_symbol": "MAML2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "12370315" ], "reference_gene_set": "REACTOME_SIGNALING_BY_NOTCH" }, { "gene_set": "IMMPRINT_NOTCH_SIGNALLING", "gene_symbol": "ADAM10", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "19726682" ], "reference_gene_set": "REACTOME_SIGNALING_BY_NOTCH" }, { "gene_set": "IMMPRINT_NOTCH_SIGNALLING", "gene_symbol": "ADAM17", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "10882063" ], "reference_gene_set": "REACTOME_SIGNALING_BY_NOTCH" }, { "gene_set": "IMMPRINT_NOTCH_SIGNALLING", "gene_symbol": "PSEN1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "10206645" ], "reference_gene_set": "REACTOME_SIGNALING_BY_NOTCH" }, { "gene_set": "IMMPRINT_NOTCH_SIGNALLING", "gene_symbol": "PSEN2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "10497236" ], "reference_gene_set": "REACTOME_SIGNALING_BY_NOTCH" }, { "gene_set": "IMMPRINT_NOTCH_SIGNALLING", "gene_symbol": "NCSTN", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "10993067" ], "reference_gene_set": "REACTOME_SIGNALING_BY_NOTCH" }, { "gene_set": "IMMPRINT_NOTCH_SIGNALLING", "gene_symbol": "POFUT1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "12697902" ], "reference_gene_set": "REACTOME_SIGNALING_BY_NOTCH" }, { "gene_set": "IMMPRINT_NOTCH_SIGNALLING", "gene_symbol": "DTX1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "context_dependent", "cell_type": "pan", "pmids": [ "9590294" ], "reference_gene_set": "REACTOME_SIGNALING_BY_NOTCH" }, { "gene_set": "IMMPRINT_OXIDATIVE_PHOSPHORYLATION", "gene_symbol": "NDUFA9", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "28671271" ], "reference_gene_set": "HALLMARK_OXIDATIVE_PHOSPHORYLATION" }, { "gene_set": "IMMPRINT_OXIDATIVE_PHOSPHORYLATION", "gene_symbol": "NDUFB8", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "29429571" ], "reference_gene_set": "HALLMARK_OXIDATIVE_PHOSPHORYLATION" }, { "gene_set": "IMMPRINT_OXIDATIVE_PHOSPHORYLATION", "gene_symbol": "NDUFS1", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "11349233" ], "reference_gene_set": "HALLMARK_OXIDATIVE_PHOSPHORYLATION" }, { "gene_set": "IMMPRINT_OXIDATIVE_PHOSPHORYLATION", "gene_symbol": "NDUFV1", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "10080174" ], "reference_gene_set": "HALLMARK_OXIDATIVE_PHOSPHORYLATION" }, { "gene_set": "IMMPRINT_OXIDATIVE_PHOSPHORYLATION", "gene_symbol": "SDHB", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "11404820" ], "reference_gene_set": "HALLMARK_OXIDATIVE_PHOSPHORYLATION" }, { "gene_set": "IMMPRINT_OXIDATIVE_PHOSPHORYLATION", "gene_symbol": "SDHC", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "11062460" ], "reference_gene_set": "HALLMARK_OXIDATIVE_PHOSPHORYLATION" }, { "gene_set": "IMMPRINT_OXIDATIVE_PHOSPHORYLATION", "gene_symbol": "SDHD", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "10657297" ], "reference_gene_set": "HALLMARK_OXIDATIVE_PHOSPHORYLATION" }, { "gene_set": "IMMPRINT_OXIDATIVE_PHOSPHORYLATION", "gene_symbol": "UQCRC1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8069229" ], "reference_gene_set": "HALLMARK_OXIDATIVE_PHOSPHORYLATION" }, { "gene_set": "IMMPRINT_OXIDATIVE_PHOSPHORYLATION", "gene_symbol": "UQCRC2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "23281071" ], "reference_gene_set": "HALLMARK_OXIDATIVE_PHOSPHORYLATION" }, { "gene_set": "IMMPRINT_OXIDATIVE_PHOSPHORYLATION", "gene_symbol": "UQCRFS1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "31883641" ], "reference_gene_set": "HALLMARK_OXIDATIVE_PHOSPHORYLATION" }, { "gene_set": "IMMPRINT_OXIDATIVE_PHOSPHORYLATION", "gene_symbol": "CYC1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "23910460" ], "reference_gene_set": "HALLMARK_OXIDATIVE_PHOSPHORYLATION" }, { "gene_set": "IMMPRINT_OXIDATIVE_PHOSPHORYLATION", "gene_symbol": "COX4I1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "28766551" ], "reference_gene_set": "HALLMARK_OXIDATIVE_PHOSPHORYLATION" }, { "gene_set": "IMMPRINT_OXIDATIVE_PHOSPHORYLATION", "gene_symbol": "COX5A", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "28247525" ], "reference_gene_set": "HALLMARK_OXIDATIVE_PHOSPHORYLATION" }, { "gene_set": "IMMPRINT_OXIDATIVE_PHOSPHORYLATION", "gene_symbol": "COX6A1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "25152455" ], "reference_gene_set": "HALLMARK_OXIDATIVE_PHOSPHORYLATION" }, { "gene_set": "IMMPRINT_OXIDATIVE_PHOSPHORYLATION", "gene_symbol": "COX7A2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2550906" ], "reference_gene_set": "HALLMARK_OXIDATIVE_PHOSPHORYLATION" }, { "gene_set": "IMMPRINT_OXIDATIVE_PHOSPHORYLATION", "gene_symbol": "ATP5F1A", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "23599390" ], "reference_gene_set": "HALLMARK_OXIDATIVE_PHOSPHORYLATION" }, { "gene_set": "IMMPRINT_OXIDATIVE_PHOSPHORYLATION", "gene_symbol": "ATP5F1B", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "36860166" ], "reference_gene_set": "HALLMARK_OXIDATIVE_PHOSPHORYLATION" }, { "gene_set": "IMMPRINT_OXIDATIVE_PHOSPHORYLATION", "gene_symbol": "ATP5F1C", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8227057" ], "reference_gene_set": "HALLMARK_OXIDATIVE_PHOSPHORYLATION" }, { "gene_set": "IMMPRINT_OXIDATIVE_PHOSPHORYLATION", "gene_symbol": "TFAM", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8333869" ], "reference_gene_set": "REACTOME_MITOCHONDRIAL_BIOGENESIS" }, { "gene_set": "IMMPRINT_OXIDATIVE_PHOSPHORYLATION", "gene_symbol": "PPARGC1A", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "10585775" ], "reference_gene_set": "REACTOME_MITOCHONDRIAL_BIOGENESIS" }, { "gene_set": "IMMPRINT_OXIDATIVE_PHOSPHORYLATION", "gene_symbol": "NRF1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2166701" ], "reference_gene_set": "REACTOME_MITOCHONDRIAL_BIOGENESIS" }, { "gene_set": "IMMPRINT_PD1_SIGNALLING", "gene_symbol": "PDCD1", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "1396582" ], "reference_gene_set": "REACTOME_CO_INHIBITION_BY_PD_1" }, { "gene_set": "IMMPRINT_PD1_SIGNALLING", "gene_symbol": "PTPN11", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "11698646" ], "reference_gene_set": "REACTOME_CO_INHIBITION_BY_PD_1" }, { "gene_set": "IMMPRINT_PD1_SIGNALLING", "gene_symbol": "PTPN6", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "15240681" ], "reference_gene_set": "REACTOME_CO_INHIBITION_BY_PD_1" }, { "gene_set": "IMMPRINT_PD1_SIGNALLING", "gene_symbol": "CSK", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "15358536" ], "reference_gene_set": "REACTOME_CO_INHIBITION_BY_PD_1" }, { "gene_set": "IMMPRINT_PD1_SIGNALLING", "gene_symbol": "CD28", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "28280247" ], "reference_gene_set": "GOBP_T_CELL_RECEPTOR_SIGNALING_PATHWAY" }, { "gene_set": "IMMPRINT_PD1_SIGNALLING", "gene_symbol": "ZAP70", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "15358536" ], "reference_gene_set": "GOBP_T_CELL_RECEPTOR_SIGNALING_PATHWAY" }, { "gene_set": "IMMPRINT_PD1_SIGNALLING", "gene_symbol": "CD247", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "15358536" ], "reference_gene_set": "REACTOME_CO_INHIBITION_BY_PD_1" }, { "gene_set": "IMMPRINT_PD1_SIGNALLING", "gene_symbol": "PIK3CD", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "16227604" ], "reference_gene_set": "GOBP_T_CELL_RECEPTOR_SIGNALING_PATHWAY" }, { "gene_set": "IMMPRINT_PROLIFERATION", "gene_symbol": "MKI67", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "6339421" ], "reference_gene_set": "HALLMARK_E2F_TARGETS" }, { "gene_set": "IMMPRINT_PROLIFERATION", "gene_symbol": "PCNA", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "102692" ], "reference_gene_set": "HALLMARK_E2F_TARGETS" }, { "gene_set": "IMMPRINT_PROLIFERATION", "gene_symbol": "MCM2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7790346" ], "reference_gene_set": "HALLMARK_E2F_TARGETS" }, { "gene_set": "IMMPRINT_PROLIFERATION", "gene_symbol": "MCM3", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8838654" ], "reference_gene_set": "HALLMARK_E2F_TARGETS" }, { "gene_set": "IMMPRINT_PROLIFERATION", "gene_symbol": "MCM5", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8838654" ], "reference_gene_set": "HALLMARK_E2F_TARGETS" }, { "gene_set": "IMMPRINT_PROLIFERATION", "gene_symbol": "MCM6", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9305914" ], "reference_gene_set": "HALLMARK_E2F_TARGETS" }, { "gene_set": "IMMPRINT_PROLIFERATION", "gene_symbol": "TOP2A", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8657123" ], "reference_gene_set": "HALLMARK_E2F_TARGETS" }, { "gene_set": "IMMPRINT_PROLIFERATION", "gene_symbol": "MYC", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "6961453" ], "reference_gene_set": "HALLMARK_E2F_TARGETS" }, { "gene_set": "IMMPRINT_PROLIFERATION", "gene_symbol": "CCNA2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2143810" ], "reference_gene_set": "REACTOME_MITOTIC_G2_G2_M_PHASES" }, { "gene_set": "IMMPRINT_PROLIFERATION", "gene_symbol": "CCNB1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2570636" ], "reference_gene_set": "REACTOME_MITOTIC_G2_G2_M_PHASES" }, { "gene_set": "IMMPRINT_PROLIFERATION", "gene_symbol": "CCND1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8491378" ], "reference_gene_set": "REACTOME_MITOTIC_G1_PHASE_AND_G1_S_TRANSITION" }, { "gene_set": "IMMPRINT_PROLIFERATION", "gene_symbol": "CCNE1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1388288" ], "reference_gene_set": "HALLMARK_E2F_TARGETS" }, { "gene_set": "IMMPRINT_PROLIFERATION", "gene_symbol": "CDK4", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1423597" ], "reference_gene_set": "HALLMARK_E2F_TARGETS" }, { "gene_set": "IMMPRINT_PROLIFERATION", "gene_symbol": "CDK6", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8114739" ], "reference_gene_set": "REACTOME_MITOTIC_G1_PHASE_AND_G1_S_TRANSITION" }, { "gene_set": "IMMPRINT_PROLIFERATION", "gene_symbol": "FOXM1", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9441747" ], "reference_gene_set": "REACTOME_MITOTIC_G2_G2_M_PHASES" }, { "gene_set": "IMMPRINT_PROLIFERATION", "gene_symbol": "E2F1", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1638634" ], "reference_gene_set": "REACTOME_MITOTIC_G2_G2_M_PHASES" }, { "gene_set": "IMMPRINT_PROLIFERATION", "gene_symbol": "AURKB", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "12925766" ], "reference_gene_set": "HALLMARK_E2F_TARGETS" }, { "gene_set": "IMMPRINT_PROLIFERATION", "gene_symbol": "BUB1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9182760", "9521327" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_PROLIFERATION", "gene_symbol": "TYMS", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2987839" ], "reference_gene_set": "REACTOME_MITOTIC_G1_PHASE_AND_G1_S_TRANSITION" }, { "gene_set": "IMMPRINT_PROLIFERATION", "gene_symbol": "RRM2", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "11978970" ], "reference_gene_set": "HALLMARK_E2F_TARGETS" }, { "gene_set": "IMMPRINT_PROLIFERATION", "gene_symbol": "CDK1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "3553962" ], "reference_gene_set": "HALLMARK_E2F_TARGETS" }, { "gene_set": "IMMPRINT_PROLIFERATION", "gene_symbol": "CDK2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1653904" ], "reference_gene_set": "REACTOME_MITOTIC_G2_G2_M_PHASES" }, { "gene_set": "IMMPRINT_PROLIFERATION", "gene_symbol": "CCNB2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7737117" ], "reference_gene_set": "HALLMARK_E2F_TARGETS" }, { "gene_set": "IMMPRINT_PROLIFERATION", "gene_symbol": "PLK1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7790358" ], "reference_gene_set": "HALLMARK_E2F_TARGETS" }, { "gene_set": "IMMPRINT_PROLIFERATION", "gene_symbol": "CDC20", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9734353" ], "reference_gene_set": "HALLMARK_E2F_TARGETS" }, { "gene_set": "IMMPRINT_PROLIFERATION", "gene_symbol": "AURKA", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9606188" ], "reference_gene_set": "HALLMARK_E2F_TARGETS" }, { "gene_set": "IMMPRINT_PROLIFERATION", "gene_symbol": "TUBA1B", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "12058064" ], "reference_gene_set": "REACTOME_MITOTIC_G2_G2_M_PHASES" }, { "gene_set": "IMMPRINT_PROLIFERATION", "gene_symbol": "TUBB4B", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "12058064" ], "reference_gene_set": "REACTOME_MITOTIC_G2_G2_M_PHASES" }, { "gene_set": "IMMPRINT_REGULATORY_RESPONSE", "gene_symbol": "FOXP3", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "11137993" ], "reference_gene_set": "GOBP_REGULATORY_T_CELL_DIFFERENTIATION" }, { "gene_set": "IMMPRINT_REGULATORY_RESPONSE", "gene_symbol": "IKZF2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "20181882" ], "reference_gene_set": "HALLMARK_IL2_STAT5_SIGNALING" }, { "gene_set": "IMMPRINT_REGULATORY_RESPONSE", "gene_symbol": "IKZF4", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "19696312" ], "reference_gene_set": "HALLMARK_IL2_STAT5_SIGNALING" }, { "gene_set": "IMMPRINT_REGULATORY_RESPONSE", "gene_symbol": "IL2RA", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "17196245" ], "reference_gene_set": "HALLMARK_IL2_STAT5_SIGNALING" }, { "gene_set": "IMMPRINT_REGULATORY_RESPONSE", "gene_symbol": "CTLA4", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "25213377" ], "reference_gene_set": "GOBP_REGULATORY_T_CELL_DIFFERENTIATION" }, { "gene_set": "IMMPRINT_REGULATORY_RESPONSE", "gene_symbol": "IL10", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2531194" ], "reference_gene_set": "HALLMARK_IL2_STAT5_SIGNALING" }, { "gene_set": "IMMPRINT_REGULATORY_RESPONSE", "gene_symbol": "TGFB1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "29483653" ], "reference_gene_set": "GOBP_REGULATORY_T_CELL_DIFFERENTIATION" }, { "gene_set": "IMMPRINT_REGULATORY_RESPONSE", "gene_symbol": "EBI3", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "18033300", "17874423" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_REGULATORY_RESPONSE", "gene_symbol": "LRRC32", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "19651619" ], "reference_gene_set": "GOBP_NEGATIVE_REGULATION_OF_LYMPHOCYTE_ACTIVATION" }, { "gene_set": "IMMPRINT_REGULATORY_RESPONSE", "gene_symbol": "TNFRSF18", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "11869690" ], "reference_gene_set": "HALLMARK_IL2_STAT5_SIGNALING" }, { "gene_set": "IMMPRINT_REGULATORY_RESPONSE", "gene_symbol": "ENTPD1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "17502665", "17449799" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_REGULATORY_RESPONSE", "gene_symbol": "NT5E", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "17502665" ], "reference_gene_set": "HALLMARK_IL2_STAT5_SIGNALING" }, { "gene_set": "IMMPRINT_REGULATORY_RESPONSE", "gene_symbol": "TIGIT", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "24745333" ], "reference_gene_set": "GOBP_NEGATIVE_REGULATION_OF_LYMPHOCYTE_ACTIVATION" }, { "gene_set": "IMMPRINT_REGULATORY_RESPONSE", "gene_symbol": "LAG3", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "15485628" ], "reference_gene_set": "GOBP_REGULATORY_T_CELL_DIFFERENTIATION" }, { "gene_set": "IMMPRINT_RLR_SIGNALLING", "gene_symbol": "DDX58", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "15208624", "25620203" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_RLR_SIGNALLING", "gene_symbol": "IFIH1", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "28716935" ], "reference_gene_set": "REACTOME_DDX58_IFIH1_MEDIATED_INDUCTION_OF_INTERFERON_ALPHA_BETA" }, { "gene_set": "IMMPRINT_RLR_SIGNALLING", "gene_symbol": "DHX58", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "16116171" ], "reference_gene_set": "REACTOME_DDX58_IFIH1_MEDIATED_INDUCTION_OF_INTERFERON_ALPHA_BETA" }, { "gene_set": "IMMPRINT_RLR_SIGNALLING", "gene_symbol": "MAVS", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "16125763" ], "reference_gene_set": "REACTOME_DDX58_IFIH1_MEDIATED_INDUCTION_OF_INTERFERON_ALPHA_BETA" }, { "gene_set": "IMMPRINT_RLR_SIGNALLING", "gene_symbol": "TBK1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "12692549" ], "reference_gene_set": "REACTOME_DDX58_IFIH1_MEDIATED_INDUCTION_OF_INTERFERON_ALPHA_BETA" }, { "gene_set": "IMMPRINT_RLR_SIGNALLING", "gene_symbol": "IKBKE", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "12692549" ], "reference_gene_set": "REACTOME_DDX58_IFIH1_MEDIATED_INDUCTION_OF_INTERFERON_ALPHA_BETA" }, { "gene_set": "IMMPRINT_RLR_SIGNALLING", "gene_symbol": "IRF3", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9463386" ], "reference_gene_set": "REACTOME_DDX58_IFIH1_MEDIATED_INDUCTION_OF_INTERFERON_ALPHA_BETA" }, { "gene_set": "IMMPRINT_RLR_SIGNALLING", "gene_symbol": "IRF7", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "25814066" ], "reference_gene_set": "REACTOME_DDX58_IFIH1_MEDIATED_INDUCTION_OF_INTERFERON_ALPHA_BETA" }, { "gene_set": "IMMPRINT_RLR_SIGNALLING", "gene_symbol": "NFKB1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2495183" ], "reference_gene_set": "REACTOME_DDX58_IFIH1_MEDIATED_INDUCTION_OF_INTERFERON_ALPHA_BETA" }, { "gene_set": "IMMPRINT_RLR_SIGNALLING", "gene_symbol": "RELA", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2495183" ], "reference_gene_set": "REACTOME_DDX58_IFIH1_MEDIATED_INDUCTION_OF_INTERFERON_ALPHA_BETA" }, { "gene_set": "IMMPRINT_RLR_SIGNALLING", "gene_symbol": "TRAF3", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "16858409" ], "reference_gene_set": "REACTOME_DDX58_IFIH1_MEDIATED_INDUCTION_OF_INTERFERON_ALPHA_BETA" }, { "gene_set": "IMMPRINT_RLR_SIGNALLING", "gene_symbol": "IFNB1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "15208624" ], "reference_gene_set": "REACTOME_DDX58_IFIH1_MEDIATED_INDUCTION_OF_INTERFERON_ALPHA_BETA" }, { "gene_set": "IMMPRINT_RLR_SIGNALLING", "gene_symbol": "IFNA1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "16039576" ], "reference_gene_set": "REACTOME_DDX58_IFIH1_MEDIATED_INDUCTION_OF_INTERFERON_ALPHA_BETA" }, { "gene_set": "IMMPRINT_RLR_SIGNALLING", "gene_symbol": "CXCL10", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "24701034" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TCR_SIGNALLING", "gene_symbol": "CD3D", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "6095101" ], "reference_gene_set": "REACTOME_TCR_SIGNALING" }, { "gene_set": "IMMPRINT_TCR_SIGNALLING", "gene_symbol": "CD3E", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "3012357" ], "reference_gene_set": "REACTOME_TCR_SIGNALING" }, { "gene_set": "IMMPRINT_TCR_SIGNALLING", "gene_symbol": "CD3G", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "2944745" ], "reference_gene_set": "REACTOME_TCR_SIGNALING" }, { "gene_set": "IMMPRINT_TCR_SIGNALLING", "gene_symbol": "CD247", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "16672702" ], "reference_gene_set": "REACTOME_TCR_SIGNALING" }, { "gene_set": "IMMPRINT_TCR_SIGNALLING", "gene_symbol": "LCK", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "1505025" ], "reference_gene_set": "REACTOME_TCR_SIGNALING" }, { "gene_set": "IMMPRINT_TCR_SIGNALLING", "gene_symbol": "FYN", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "1516132" ], "reference_gene_set": "REACTOME_FC_EPSILON_RECEPTOR_FCERI_SIGNALING" }, { "gene_set": "IMMPRINT_TCR_SIGNALLING", "gene_symbol": "ZAP70", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "1423621" ], "reference_gene_set": "REACTOME_TCR_SIGNALING" }, { "gene_set": "IMMPRINT_TCR_SIGNALLING", "gene_symbol": "LAT", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "9489702" ], "reference_gene_set": "REACTOME_TCR_SIGNALING" }, { "gene_set": "IMMPRINT_TCR_SIGNALLING", "gene_symbol": "LCP2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "9665884" ], "reference_gene_set": "REACTOME_TCR_SIGNALING" }, { "gene_set": "IMMPRINT_TCR_SIGNALLING", "gene_symbol": "PLCG1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "1712101" ], "reference_gene_set": "REACTOME_TCR_SIGNALING" }, { "gene_set": "IMMPRINT_TCR_SIGNALLING", "gene_symbol": "ITK", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "19425169" ], "reference_gene_set": "REACTOME_TCR_SIGNALING" }, { "gene_set": "IMMPRINT_TCR_SIGNALLING", "gene_symbol": "PRKCQ", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "10746729" ], "reference_gene_set": "REACTOME_TCR_SIGNALING" }, { "gene_set": "IMMPRINT_TCR_SIGNALLING", "gene_symbol": "CARD11", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "12154360" ], "reference_gene_set": "REACTOME_TCR_SIGNALING" }, { "gene_set": "IMMPRINT_TCR_SIGNALLING", "gene_symbol": "BCL10", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "25365219" ], "reference_gene_set": "REACTOME_TCR_SIGNALING" }, { "gene_set": "IMMPRINT_TCR_SIGNALLING", "gene_symbol": "MALT1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "23727036" ], "reference_gene_set": "REACTOME_TCR_SIGNALING" }, { "gene_set": "IMMPRINT_TCR_SIGNALLING", "gene_symbol": "NFATC1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "8202141" ], "reference_gene_set": "REACTOME_FC_EPSILON_RECEPTOR_FCERI_SIGNALING" }, { "gene_set": "IMMPRINT_TCR_SIGNALLING", "gene_symbol": "NFKB1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "8383323" ], "reference_gene_set": "REACTOME_TCR_SIGNALING" }, { "gene_set": "IMMPRINT_TCR_SIGNALLING", "gene_symbol": "RELA", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "8383323" ], "reference_gene_set": "REACTOME_TCR_SIGNALING" }, { "gene_set": "IMMPRINT_TCR_SIGNALLING", "gene_symbol": "VAV1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "10077632" ], "reference_gene_set": "REACTOME_FC_EPSILON_RECEPTOR_FCERI_SIGNALING" }, { "gene_set": "IMMPRINT_TGFB_SIGNALLING", "gene_symbol": "TGFBR1", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8242743" ], "reference_gene_set": "REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX" }, { "gene_set": "IMMPRINT_TGFB_SIGNALLING", "gene_symbol": "TGFBR2", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1310899" ], "reference_gene_set": "REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX" }, { "gene_set": "IMMPRINT_TGFB_SIGNALLING", "gene_symbol": "TGFBR3", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1657406" ], "reference_gene_set": "REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX" }, { "gene_set": "IMMPRINT_TGFB_SIGNALLING", "gene_symbol": "ACVR1B", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8242742" ], "reference_gene_set": "REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS" }, { "gene_set": "IMMPRINT_TGFB_SIGNALLING", "gene_symbol": "ACVR2A", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1646080" ], "reference_gene_set": "REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS" }, { "gene_set": "IMMPRINT_TGFB_SIGNALLING", "gene_symbol": "SMAD2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8752209" ], "reference_gene_set": "REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX" }, { "gene_set": "IMMPRINT_TGFB_SIGNALLING", "gene_symbol": "SMAD3", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9311995" ], "reference_gene_set": "REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX" }, { "gene_set": "IMMPRINT_TGFB_SIGNALLING", "gene_symbol": "SMAD4", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8893010" ], "reference_gene_set": "REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX" }, { "gene_set": "IMMPRINT_TGFB_SIGNALLING", "gene_symbol": "SMAD6", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "inhibitory", "cell_type": "pan", "pmids": [ "9335505" ], "reference_gene_set": "REACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS" }, { "gene_set": "IMMPRINT_TGFB_SIGNALLING", "gene_symbol": "SMAD7", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "inhibitory", "cell_type": "pan", "pmids": [ "9335507" ], "reference_gene_set": "REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX" }, { "gene_set": "IMMPRINT_TGFB_SIGNALLING", "gene_symbol": "SKI", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "inhibitory", "cell_type": "pan", "pmids": [ "10485843" ], "reference_gene_set": "REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX" }, { "gene_set": "IMMPRINT_TGFB_SIGNALLING", "gene_symbol": "SKIL", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "inhibitory", "cell_type": "pan", "pmids": [ "10531062" ], "reference_gene_set": "REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX" }, { "gene_set": "IMMPRINT_TGFB_SIGNALLING", "gene_symbol": "SERPINE1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9606191" ], "reference_gene_set": "REACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX" }, { "gene_set": "IMMPRINT_TGFB_SIGNALLING", "gene_symbol": "CCN2", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9052988", "12571253" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TGFB_SIGNALLING", "gene_symbol": "ZEB1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "17615296", "12743039" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TISSUE_RESIDENCY", "gene_symbol": "CXCR6", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "11238560", "31558615" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TISSUE_RESIDENCY", "gene_symbol": "ITGAE", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "24162776", "10352281" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TISSUE_RESIDENCY", "gene_symbol": "CD69", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "16525420", "20463015" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TISSUE_RESIDENCY", "gene_symbol": "ITGA1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "14975239", "28214226" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TISSUE_RESIDENCY", "gene_symbol": "PRDM1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "27102484", "30899267" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TISSUE_RESIDENCY", "gene_symbol": "ZNF683", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "27102484", "35389518" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TISSUE_RESIDENCY", "gene_symbol": "RUNX3", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "29211713", "37269830" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TISSUE_RESIDENCY", "gene_symbol": "AHR", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "21999944", "36640340" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TISSUE_RESIDENCY", "gene_symbol": "NOTCH1", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "27776108", "31071093" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TISSUE_RESIDENCY", "gene_symbol": "RBPJ", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "27776108", "31071093" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TLR_SIGNALLING", "gene_symbol": "TLR1", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "12077222" ], "reference_gene_set": "REACTOME_TOLL_LIKE_RECEPTOR_CASCADES" }, { "gene_set": "IMMPRINT_TLR_SIGNALLING", "gene_symbol": "TLR2", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "10549626" ], "reference_gene_set": "REACTOME_TOLL_LIKE_RECEPTOR_CASCADES" }, { "gene_set": "IMMPRINT_TLR_SIGNALLING", "gene_symbol": "TLR3", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "11607032" ], "reference_gene_set": "REACTOME_TOLL_LIKE_RECEPTOR_CASCADES" }, { "gene_set": "IMMPRINT_TLR_SIGNALLING", "gene_symbol": "TLR4", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "10835634" ], "reference_gene_set": "REACTOME_TOLL_LIKE_RECEPTOR_CASCADES" }, { "gene_set": "IMMPRINT_TLR_SIGNALLING", "gene_symbol": "TLR5", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "11323673" ], "reference_gene_set": "REACTOME_TOLL_LIKE_RECEPTOR_CASCADES" }, { "gene_set": "IMMPRINT_TLR_SIGNALLING", "gene_symbol": "TLR6", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "11431423" ], "reference_gene_set": "REACTOME_TOLL_LIKE_RECEPTOR_CASCADES" }, { "gene_set": "IMMPRINT_TLR_SIGNALLING", "gene_symbol": "TLR7", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "34413140" ], "reference_gene_set": "REACTOME_TOLL_LIKE_RECEPTOR_CASCADES" }, { "gene_set": "IMMPRINT_TLR_SIGNALLING", "gene_symbol": "TLR8", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "14976262" ], "reference_gene_set": "REACTOME_TOLL_LIKE_RECEPTOR_CASCADES" }, { "gene_set": "IMMPRINT_TLR_SIGNALLING", "gene_symbol": "TLR9", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "11130078" ], "reference_gene_set": "REACTOME_TOLL_LIKE_RECEPTOR_CASCADES" }, { "gene_set": "IMMPRINT_TLR_SIGNALLING", "gene_symbol": "MYD88", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9734363" ], "reference_gene_set": "REACTOME_TOLL_LIKE_RECEPTOR_CASCADES" }, { "gene_set": "IMMPRINT_TLR_SIGNALLING", "gene_symbol": "TICAM1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "12539043" ], "reference_gene_set": "REACTOME_TOLL_LIKE_RECEPTOR_CASCADES" }, { "gene_set": "IMMPRINT_TLR_SIGNALLING", "gene_symbol": "TIRAP", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "11526399" ], "reference_gene_set": "REACTOME_TOLL_LIKE_RECEPTOR_CASCADES" }, { "gene_set": "IMMPRINT_TLR_SIGNALLING", "gene_symbol": "TICAM2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "14519765" ], "reference_gene_set": "REACTOME_TOLL_LIKE_RECEPTOR_CASCADES" }, { "gene_set": "IMMPRINT_TLR_SIGNALLING", "gene_symbol": "IRAK1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8599092" ], "reference_gene_set": "REACTOME_TOLL_LIKE_RECEPTOR_CASCADES" }, { "gene_set": "IMMPRINT_TLR_SIGNALLING", "gene_symbol": "IRAK4", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "12637671" ], "reference_gene_set": "REACTOME_TOLL_LIKE_RECEPTOR_CASCADES" }, { "gene_set": "IMMPRINT_TLR_SIGNALLING", "gene_symbol": "TRAF6", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8837778" ], "reference_gene_set": "REACTOME_TOLL_LIKE_RECEPTOR_CASCADES" }, { "gene_set": "IMMPRINT_TLR_SIGNALLING", "gene_symbol": "TBK1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "22851595" ], "reference_gene_set": "REACTOME_TOLL_LIKE_RECEPTOR_CASCADES" }, { "gene_set": "IMMPRINT_TLR_SIGNALLING", "gene_symbol": "IKBKE", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "15210742" ], "reference_gene_set": "REACTOME_TOLL_LIKE_RECEPTOR_CASCADES" }, { "gene_set": "IMMPRINT_TLR_SIGNALLING", "gene_symbol": "IRF3", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "26216125" ], "reference_gene_set": "REACTOME_TOLL_LIKE_RECEPTOR_CASCADES" }, { "gene_set": "IMMPRINT_TLR_SIGNALLING", "gene_symbol": "IRF7", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "15361868" ], "reference_gene_set": "REACTOME_TOLL_LIKE_RECEPTOR_CASCADES" }, { "gene_set": "IMMPRINT_TLR_SIGNALLING", "gene_symbol": "NFKB1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9237759" ], "reference_gene_set": "REACTOME_TOLL_LIKE_RECEPTOR_CASCADES" }, { "gene_set": "IMMPRINT_TLR_SIGNALLING", "gene_symbol": "RELA", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9237759" ], "reference_gene_set": "REACTOME_TOLL_LIKE_RECEPTOR_CASCADES" }, { "gene_set": "IMMPRINT_TLR_SIGNALLING", "gene_symbol": "TNF", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "10201887" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TLR_SIGNALLING", "gene_symbol": "IL6", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "10201887" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TLR_SIGNALLING", "gene_symbol": "IFNB1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "12354379" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TLR_SIGNALLING", "gene_symbol": "CXCL10", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "12354379" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TNF_SIGNALLING", "gene_symbol": "TNFRSF1A", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "10626900" ], "reference_gene_set": "REACTOME_TNF_SIGNALING" }, { "gene_set": "IMMPRINT_TNF_SIGNALLING", "gene_symbol": "TNFRSF1B", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "10626900" ], "reference_gene_set": "GOBP_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY" }, { "gene_set": "IMMPRINT_TNF_SIGNALLING", "gene_symbol": "TRADD", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7758105" ], "reference_gene_set": "REACTOME_TNF_SIGNALING" }, { "gene_set": "IMMPRINT_TNF_SIGNALLING", "gene_symbol": "TRAF2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8069916" ], "reference_gene_set": "REACTOME_TNF_SIGNALING" }, { "gene_set": "IMMPRINT_TNF_SIGNALLING", "gene_symbol": "TRAF5", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "11479302" ], "reference_gene_set": "GOBP_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY" }, { "gene_set": "IMMPRINT_TNF_SIGNALLING", "gene_symbol": "RIPK1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8612133" ], "reference_gene_set": "REACTOME_TNF_SIGNALING" }, { "gene_set": "IMMPRINT_TNF_SIGNALLING", "gene_symbol": "FADD", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8565075" ], "reference_gene_set": "REACTOME_TNF_SIGNALING" }, { "gene_set": "IMMPRINT_TNF_SIGNALLING", "gene_symbol": "NFKB1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2494664" ], "reference_gene_set": "GOBP_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY" }, { "gene_set": "IMMPRINT_TNF_SIGNALLING", "gene_symbol": "RELA", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2494664" ], "reference_gene_set": "GOBP_TUMOR_NECROSIS_FACTOR_MEDIATED_SIGNALING_PATHWAY" }, { "gene_set": "IMMPRINT_TNF_SIGNALLING", "gene_symbol": "CHUK", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9346484" ], "reference_gene_set": "REACTOME_TNF_SIGNALING" }, { "gene_set": "IMMPRINT_TNF_SIGNALLING", "gene_symbol": "IKBKB", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9346485" ], "reference_gene_set": "REACTOME_TNF_SIGNALING" }, { "gene_set": "IMMPRINT_TNF_SIGNALLING", "gene_symbol": "IKBKG", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9751060" ], "reference_gene_set": "REACTOME_TNF_SIGNALING" }, { "gene_set": "IMMPRINT_TNF_SIGNALLING", "gene_symbol": "CASP8", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8681376" ], "reference_gene_set": "REACTOME_TNF_SIGNALING" }, { "gene_set": "IMMPRINT_TNF_SIGNALLING", "gene_symbol": "BIRC2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8548810" ], "reference_gene_set": "REACTOME_TNF_SIGNALING" }, { "gene_set": "IMMPRINT_TNF_SIGNALLING", "gene_symbol": "BIRC3", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8548810" ], "reference_gene_set": "REACTOME_TNF_SIGNALING" }, { "gene_set": "IMMPRINT_TNF_SIGNALLING", "gene_symbol": "CCL2", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "18656701" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TNF_SIGNALLING", "gene_symbol": "VCAM1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Endothelial", "pmids": [ "7541294" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TNF_SIGNALLING", "gene_symbol": "CXCL8", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8166294" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TNF_SIGNALLING", "gene_symbol": "IL6", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8034659" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TYPE17_RESPONSE", "gene_symbol": "RORC", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "26160376" ], "reference_gene_set": "GOBP_T_HELPER_17_CELL_DIFFERENTIATION" }, { "gene_set": "IMMPRINT_TYPE17_RESPONSE", "gene_symbol": "RORA", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "18164222" ], "reference_gene_set": "GOBP_T_HELPER_17_CELL_DIFFERENTIATION" }, { "gene_set": "IMMPRINT_TYPE17_RESPONSE", "gene_symbol": "STAT3", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "17676033" ], "reference_gene_set": "GOBP_T_HELPER_17_CELL_DIFFERENTIATION" }, { "gene_set": "IMMPRINT_TYPE17_RESPONSE", "gene_symbol": "IRF4", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "17676043" ], "reference_gene_set": "GOBP_T_HELPER_17_CELL_DIFFERENTIATION" }, { "gene_set": "IMMPRINT_TYPE17_RESPONSE", "gene_symbol": "BATF", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "19578362" ], "reference_gene_set": "GOBP_T_HELPER_17_CELL_DIFFERENTIATION" }, { "gene_set": "IMMPRINT_TYPE17_RESPONSE", "gene_symbol": "AHR", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "18362914", "18607004" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TYPE17_RESPONSE", "gene_symbol": "IL17A", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "16200068" ], "reference_gene_set": "GOBP_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE" }, { "gene_set": "IMMPRINT_TYPE17_RESPONSE", "gene_symbol": "IL17F", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "21350122" ], "reference_gene_set": "GOBP_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE" }, { "gene_set": "IMMPRINT_TYPE17_RESPONSE", "gene_symbol": "IL22", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "16982811", "15308104" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TYPE17_RESPONSE", "gene_symbol": "IL26", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "17676044", "23055831" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TYPE17_RESPONSE", "gene_symbol": "IL21", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "17581589" ], "reference_gene_set": "GOBP_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE" }, { "gene_set": "IMMPRINT_TYPE17_RESPONSE", "gene_symbol": "IL23R", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "12023369" ], "reference_gene_set": "GOBP_T_HELPER_17_CELL_DIFFERENTIATION" }, { "gene_set": "IMMPRINT_TYPE17_RESPONSE", "gene_symbol": "IL12RB1", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "12023369" ], "reference_gene_set": "GOBP_T_HELPER_17_CELL_DIFFERENTIATION" }, { "gene_set": "IMMPRINT_TYPE17_RESPONSE", "gene_symbol": "IL1R1", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "19362022" ], "reference_gene_set": "GOBP_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE" }, { "gene_set": "IMMPRINT_TYPE17_RESPONSE", "gene_symbol": "CCR6", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "17486092" ], "reference_gene_set": "GOBP_PRODUCTION_OF_MOLECULAR_MEDIATOR_OF_IMMUNE_RESPONSE" }, { "gene_set": "IMMPRINT_TYPE1_RESPONSE", "gene_symbol": "TBX21", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "10761931" ], "reference_gene_set": "GOBP_T_HELPER_1_CELL_DIFFERENTIATION" }, { "gene_set": "IMMPRINT_TYPE1_RESPONSE", "gene_symbol": "STAT1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "11452125" ], "reference_gene_set": "REACTOME_DIFFERENTIATION_OF_NAIVE_CD_T_CELLS_TO_T_HELPER_1_CELLS_TH1_CELLS" }, { "gene_set": "IMMPRINT_TYPE1_RESPONSE", "gene_symbol": "STAT4", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8700209" ], "reference_gene_set": "GOBP_T_HELPER_1_CELL_DIFFERENTIATION" }, { "gene_set": "IMMPRINT_TYPE1_RESPONSE", "gene_symbol": "RUNX3", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "17195845" ], "reference_gene_set": "REACTOME_DIFFERENTIATION_OF_NAIVE_CD_T_CELLS_TO_T_HELPER_1_CELLS_TH1_CELLS" }, { "gene_set": "IMMPRINT_TYPE1_RESPONSE", "gene_symbol": "EOMES", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "14605368", "16273099" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TYPE1_RESPONSE", "gene_symbol": "IFNG", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2960769" ], "reference_gene_set": "REACTOME_DIFFERENTIATION_OF_NAIVE_CD_T_CELLS_TO_T_HELPER_1_CELLS_TH1_CELLS" }, { "gene_set": "IMMPRINT_TYPE1_RESPONSE", "gene_symbol": "TNF", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "6392892" ], "reference_gene_set": "REACTOME_DIFFERENTIATION_OF_NAIVE_CD_T_CELLS_TO_T_HELPER_1_CELLS_TH1_CELLS" }, { "gene_set": "IMMPRINT_TYPE1_RESPONSE", "gene_symbol": "LTA", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "6334807" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TYPE1_RESPONSE", "gene_symbol": "IL12RB1", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8943050" ], "reference_gene_set": "HALLMARK_ALLOGRAFT_REJECTION" }, { "gene_set": "IMMPRINT_TYPE1_RESPONSE", "gene_symbol": "IL12RB2", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9120388" ], "reference_gene_set": "REACTOME_DIFFERENTIATION_OF_NAIVE_CD_T_CELLS_TO_T_HELPER_1_CELLS_TH1_CELLS" }, { "gene_set": "IMMPRINT_TYPE1_RESPONSE", "gene_symbol": "IL18R1", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9782125" ], "reference_gene_set": "GOBP_T_HELPER_1_CELL_DIFFERENTIATION" }, { "gene_set": "IMMPRINT_TYPE1_RESPONSE", "gene_symbol": "IL18RAP", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9792649" ], "reference_gene_set": "GOBP_T_HELPER_1_CELL_DIFFERENTIATION" }, { "gene_set": "IMMPRINT_TYPE1_RESPONSE", "gene_symbol": "CXCR3", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9419219" ], "reference_gene_set": "REACTOME_DIFFERENTIATION_OF_NAIVE_CD_T_CELLS_TO_T_HELPER_1_CELLS_TH1_CELLS" }, { "gene_set": "IMMPRINT_TYPE1_RESPONSE", "gene_symbol": "CCR5", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9419219" ], "reference_gene_set": "HALLMARK_ALLOGRAFT_REJECTION" }, { "gene_set": "IMMPRINT_TYPE2_RESPONSE", "gene_symbol": "GATA3", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9261181" ], "reference_gene_set": "GOBP_T_HELPER_2_CELL_DIFFERENTIATION" }, { "gene_set": "IMMPRINT_TYPE2_RESPONSE", "gene_symbol": "STAT6", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "36884218" ], "reference_gene_set": "REACTOME_INTERLEUKIN_4_AND_INTERLEUKIN_13_SIGNALING" }, { "gene_set": "IMMPRINT_TYPE2_RESPONSE", "gene_symbol": "IRF4", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "11956291" ], "reference_gene_set": "REACTOME_INTERLEUKIN_4_AND_INTERLEUKIN_13_SIGNALING" }, { "gene_set": "IMMPRINT_TYPE2_RESPONSE", "gene_symbol": "IL4", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8384701" ], "reference_gene_set": "REACTOME_INTERLEUKIN_4_AND_INTERLEUKIN_13_SIGNALING" }, { "gene_set": "IMMPRINT_TYPE2_RESPONSE", "gene_symbol": "IL5", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2960769", "2230651" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TYPE2_RESPONSE", "gene_symbol": "IL13", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9768762" ], "reference_gene_set": "REACTOME_INTERLEUKIN_4_AND_INTERLEUKIN_13_SIGNALING" }, { "gene_set": "IMMPRINT_TYPE2_RESPONSE", "gene_symbol": "IL9", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "7930607" ], "reference_gene_set": "GOBP_INTERLEUKIN_5_PRODUCTION" }, { "gene_set": "IMMPRINT_TYPE2_RESPONSE", "gene_symbol": "IL31", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "15184896", "16461142" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TYPE2_RESPONSE", "gene_symbol": "IL4R", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2805066" ], "reference_gene_set": "REACTOME_INTERLEUKIN_4_AND_INTERLEUKIN_13_SIGNALING" }, { "gene_set": "IMMPRINT_TYPE2_RESPONSE", "gene_symbol": "IL13RA1", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8552669" ], "reference_gene_set": "REACTOME_INTERLEUKIN_4_AND_INTERLEUKIN_13_SIGNALING" }, { "gene_set": "IMMPRINT_TYPE2_RESPONSE", "gene_symbol": "IL1RL1", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9480988" ], "reference_gene_set": "GOBP_INTERLEUKIN_5_PRODUCTION" }, { "gene_set": "IMMPRINT_TYPE2_RESPONSE", "gene_symbol": "IL17RB", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "17562814" ], "reference_gene_set": "GOBP_INTERLEUKIN_5_PRODUCTION" }, { "gene_set": "IMMPRINT_TYPE2_RESPONSE", "gene_symbol": "CCR4", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9820476", "10050676" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TYPE2_RESPONSE", "gene_symbol": "CCR8", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9820476", "9670926" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TYPE2_RESPONSE", "gene_symbol": "PTGDR2", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "11208866", "10518017" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_WNT_SIGNALLING", "gene_symbol": "FZD1", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8717036" ], "reference_gene_set": "REACTOME_SIGNALING_BY_WNT" }, { "gene_set": "IMMPRINT_WNT_SIGNALLING", "gene_symbol": "FZD2", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8717036" ], "reference_gene_set": "REACTOME_SIGNALING_BY_WNT" }, { "gene_set": "IMMPRINT_WNT_SIGNALLING", "gene_symbol": "FZD7", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8717036" ], "reference_gene_set": "REACTOME_SIGNALING_BY_WNT" }, { "gene_set": "IMMPRINT_WNT_SIGNALLING", "gene_symbol": "LRP5", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "11719191" ], "reference_gene_set": "REACTOME_SIGNALING_BY_WNT" }, { "gene_set": "IMMPRINT_WNT_SIGNALLING", "gene_symbol": "LRP6", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "11029007" ], "reference_gene_set": "REACTOME_SIGNALING_BY_WNT" }, { "gene_set": "IMMPRINT_WNT_SIGNALLING", "gene_symbol": "DVL1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "25817016" ], "reference_gene_set": "REACTOME_SIGNALING_BY_WNT" }, { "gene_set": "IMMPRINT_WNT_SIGNALLING", "gene_symbol": "DVL2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8288125" ], "reference_gene_set": "REACTOME_SIGNALING_BY_WNT" }, { "gene_set": "IMMPRINT_WNT_SIGNALLING", "gene_symbol": "DVL3", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "26924530" ], "reference_gene_set": "REACTOME_SIGNALING_BY_WNT" }, { "gene_set": "IMMPRINT_WNT_SIGNALLING", "gene_symbol": "APC", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "inhibitory", "cell_type": "pan", "pmids": [ "8259518" ], "reference_gene_set": "REACTOME_SIGNALING_BY_WNT" }, { "gene_set": "IMMPRINT_WNT_SIGNALLING", "gene_symbol": "AXIN1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "inhibitory", "cell_type": "pan", "pmids": [ "9230313" ], "reference_gene_set": "REACTOME_SIGNALING_BY_WNT" }, { "gene_set": "IMMPRINT_WNT_SIGNALLING", "gene_symbol": "AXIN2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "inhibitory", "cell_type": "pan", "pmids": [ "11809808" ], "reference_gene_set": "REACTOME_SIGNALING_BY_WNT" }, { "gene_set": "IMMPRINT_WNT_SIGNALLING", "gene_symbol": "CTNNB1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9065402" ], "reference_gene_set": "REACTOME_SIGNALING_BY_WNT" }, { "gene_set": "IMMPRINT_WNT_SIGNALLING", "gene_symbol": "GSK3B", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "inhibitory", "cell_type": "pan", "pmids": [ "12554650" ], "reference_gene_set": "REACTOME_SIGNALING_BY_WNT" }, { "gene_set": "IMMPRINT_WNT_SIGNALLING", "gene_symbol": "CSNK1A1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "inhibitory", "cell_type": "pan", "pmids": [ "11955436" ], "reference_gene_set": "REACTOME_SIGNALING_BY_WNT" }, { "gene_set": "IMMPRINT_WNT_SIGNALLING", "gene_symbol": "TCF7", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "10489374" ], "reference_gene_set": "REACTOME_SIGNALING_BY_WNT" }, { "gene_set": "IMMPRINT_WNT_SIGNALLING", "gene_symbol": "TCF7L2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "9065401" ], "reference_gene_set": "REACTOME_SIGNALING_BY_WNT" }, { "gene_set": "IMMPRINT_WNT_SIGNALLING", "gene_symbol": "LEF1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2010090" ], "reference_gene_set": "REACTOME_SIGNALING_BY_WNT" }, { "gene_set": "IMMPRINT_WNT_SIGNALLING", "gene_symbol": "CCND1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "10201372", "10318916" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_CSF2_SIGNALLING", "gene_symbol": "CSF2RA", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2555171" ], "reference_gene_set": "REACTOME_INTERLEUKIN_3_INTERLEUKIN_5_AND_GM_CSF_SIGNALING" }, { "gene_set": "IMMPRINT_CSF2_SIGNALLING", "gene_symbol": "CSF2RB", "pathway_level": 1, "pathway_level_label": "Receptor", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1702217" ], "reference_gene_set": "REACTOME_INTERLEUKIN_3_INTERLEUKIN_5_AND_GM_CSF_SIGNALING" }, { "gene_set": "IMMPRINT_CSF2_SIGNALLING", "gene_symbol": "JAK2", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8007942" ], "reference_gene_set": "REACTOME_INTERLEUKIN_3_INTERLEUKIN_5_AND_GM_CSF_SIGNALING" }, { "gene_set": "IMMPRINT_CSF2_SIGNALLING", "gene_symbol": "STAT5A", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "11867689" ], "reference_gene_set": "REACTOME_INTERLEUKIN_3_INTERLEUKIN_5_AND_GM_CSF_SIGNALING" }, { "gene_set": "IMMPRINT_CSF2_SIGNALLING", "gene_symbol": "STAT5B", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "11867689" ], "reference_gene_set": "REACTOME_INTERLEUKIN_3_INTERLEUKIN_5_AND_GM_CSF_SIGNALING" }, { "gene_set": "IMMPRINT_CSF2_SIGNALLING", "gene_symbol": "PTPN11", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "context_dependent", "cell_type": "pan", "pmids": [ "7522233" ], "reference_gene_set": "REACTOME_INTERLEUKIN_3_INTERLEUKIN_5_AND_GM_CSF_SIGNALING" }, { "gene_set": "IMMPRINT_CSF2_SIGNALLING", "gene_symbol": "PIK3R1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "12429725" ], "reference_gene_set": "REACTOME_INTERLEUKIN_3_INTERLEUKIN_5_AND_GM_CSF_SIGNALING" }, { "gene_set": "IMMPRINT_CSF2_SIGNALLING", "gene_symbol": "AKT1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "15259023", "20173116" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_CSF2_SIGNALLING", "gene_symbol": "CISH", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "inhibitory", "cell_type": "pan", "pmids": [ "11867689" ], "reference_gene_set": "HALLMARK_IL2_STAT5_SIGNALING" }, { "gene_set": "IMMPRINT_CSF2_SIGNALLING", "gene_symbol": "PIM1", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "1314369" ], "reference_gene_set": "HALLMARK_IL2_STAT5_SIGNALING" }, { "gene_set": "IMMPRINT_CSF2_SIGNALLING", "gene_symbol": "CCL17", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "27525438" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL17_SIGNALLING", "gene_symbol": "S100A7", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Epithelial", "pmids": [ "18684158" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL17_SIGNALLING", "gene_symbol": "CCL20", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Epithelial; Fibroblast", "pmids": [ "19295614" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL17_SIGNALLING", "gene_symbol": "LCN2", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Epithelial", "pmids": [ "21085185" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL17_SIGNALLING", "gene_symbol": "IL6", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8676080" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL17_SIGNALLING", "gene_symbol": "CSF3", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "8676080" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IFNG_SIGNALLING", "gene_symbol": "FCGR1A", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Monocyte/Macrophage", "pmids": [ "6192145" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IFNG_SIGNALLING", "gene_symbol": "IL12B", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Monocyte/Macrophage", "pmids": [ "8551218" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IFNG_SIGNALLING", "gene_symbol": "CYBB", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Monocyte/Macrophage", "pmids": [ "15067074" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TNF_SIGNALLING", "gene_symbol": "ICAM1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "3091693" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TNF_SIGNALLING", "gene_symbol": "SELE", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Endothelial", "pmids": [ "2827173" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TNF_SIGNALLING", "gene_symbol": "MMP1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Fibroblast", "pmids": [ "2999289" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TNF_SIGNALLING", "gene_symbol": "MMP3", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Fibroblast", "pmids": [ "1698773" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL4_IL13_SIGNALLING", "gene_symbol": "MRC1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Monocyte/Macrophage", "pmids": [ "9120298" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL4_IL13_SIGNALLING", "gene_symbol": "FCER2", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "B cell; Monocyte/Macrophage", "pmids": [ "2965737" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL4_IL13_SIGNALLING", "gene_symbol": "MUC5AC", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Epithelial", "pmids": [ "21275604" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL4_IL13_SIGNALLING", "gene_symbol": "CLCA1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Epithelial", "pmids": [ "21275604" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL4_IL13_SIGNALLING", "gene_symbol": "IGHE", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "B cell", "pmids": [ "1695667" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL6_SIGNALLING", "gene_symbol": "IL21", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "22491065" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TGFB_SIGNALLING", "gene_symbol": "FOXP3", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "14676299" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TGFB_SIGNALLING", "gene_symbol": "IGHA1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "B cell", "pmids": [ "2339132" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TGFB_SIGNALLING", "gene_symbol": "ACTA2", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Fibroblast", "pmids": [ "8314838" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TGFB_SIGNALLING", "gene_symbol": "FN1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Epithelial; Fibroblast", "pmids": [ "3456347" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TGFB_SIGNALLING", "gene_symbol": "SNAI1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Epithelial", "pmids": [ "24126595" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TGFB_SIGNALLING", "gene_symbol": "VIM", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Epithelial", "pmids": [ "24126595" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL10_SIGNALLING", "gene_symbol": "CD163", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Monocyte/Macrophage", "pmids": [ "10648003" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL10_SIGNALLING", "gene_symbol": "TIMP1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Monocyte/Macrophage", "pmids": [ "7593617" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL10_SIGNALLING", "gene_symbol": "NFIL3", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Monocyte/Macrophage", "pmids": [ "21566115" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TNF_SIGNALLING", "gene_symbol": "CX3CL1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Endothelial", "pmids": [ "15111313" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TNF_SIGNALLING", "gene_symbol": "F3", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Endothelial", "pmids": [ "2718149" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TNF_SIGNALLING", "gene_symbol": "MMP14", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Fibroblast", "pmids": [ "11112697" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TNF_SIGNALLING", "gene_symbol": "TNFAIP3", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "inhibitory", "cell_type": "pan", "pmids": [ "8692885" ], "reference_gene_set": "" }, { "gene_set": "IMMPRINT_TNF_SIGNALLING", "gene_symbol": "NFKBIA", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "inhibitory", "cell_type": "pan", "pmids": [ "7796813" ], "reference_gene_set": "" }, { "gene_set": "IMMPRINT_IL4_IL13_SIGNALLING", "gene_symbol": "CCL18", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Monocyte/Macrophage", "pmids": [ "37949903" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL4_IL13_SIGNALLING", "gene_symbol": "ALOX15", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Monocyte/Macrophage", "pmids": [ "1729692" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL4_IL13_SIGNALLING", "gene_symbol": "TGM2", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Monocyte/Macrophage", "pmids": [ "32032932" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL4_IL13_SIGNALLING", "gene_symbol": "IGHG4", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "B cell", "pmids": [ "8097323" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL4_IL13_SIGNALLING", "gene_symbol": "IL4I1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "B cell", "pmids": [ "12031486" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL4_IL13_SIGNALLING", "gene_symbol": "POSTN", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Epithelial", "pmids": [ "17898169" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL4_IL13_SIGNALLING", "gene_symbol": "SERPINB2", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Epithelial", "pmids": [ "17898169" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL4_IL13_SIGNALLING", "gene_symbol": "CAPN14", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Epithelial", "pmids": [ "27158675" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL4_IL13_SIGNALLING", "gene_symbol": "GATA3", "pathway_level": 2, "pathway_level_label": "Transducer", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "20620947" ], "reference_gene_set": "" }, { "gene_set": "IMMPRINT_IL6_SIGNALLING", "gene_symbol": "BCL6", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "22491065" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL6_SIGNALLING", "gene_symbol": "ICOS", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "23923047" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TGFB_SIGNALLING", "gene_symbol": "ITGAE", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "T cell", "pmids": [ "24477908" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TGFB_SIGNALLING", "gene_symbol": "COL1A1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Fibroblast", "pmids": [ "3501287" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TGFB_SIGNALLING", "gene_symbol": "COL3A1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Fibroblast", "pmids": [ "3501287" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TGFB_SIGNALLING", "gene_symbol": "POSTN", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Fibroblast", "pmids": [ "30186543" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TGFB_SIGNALLING", "gene_symbol": "TAGLN", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Fibroblast", "pmids": [ "30413733" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TGFB_SIGNALLING", "gene_symbol": "SNAI2", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Epithelial", "pmids": [ "21169525" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TGFB_SIGNALLING", "gene_symbol": "CDH2", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Epithelial", "pmids": [ "21169525" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL10_SIGNALLING", "gene_symbol": "FCGR3A", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Monocyte/Macrophage", "pmids": [ "8734788" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL17_SIGNALLING", "gene_symbol": "CXCL1", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "26839464" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_TGFB_SIGNALLING", "gene_symbol": "IGHA2", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "B cell", "pmids": [ "1760405" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL10_SIGNALLING", "gene_symbol": "MERTK", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "Monocyte/Macrophage", "pmids": [ "22942426" ], "reference_gene_set": null }, { "gene_set": "IMMPRINT_IL1_SIGNALLING", "gene_symbol": "CXCL8", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2478449" ], "reference_gene_set": "" }, { "gene_set": "IMMPRINT_IL1_SIGNALLING", "gene_symbol": "CCL2", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "2182712" ], "reference_gene_set": "" }, { "gene_set": "IMMPRINT_IL1_SIGNALLING", "gene_symbol": "IL6", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "3493322" ], "reference_gene_set": "" }, { "gene_set": "IMMPRINT_IL17_SIGNALLING", "gene_symbol": "S100A8", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "16982811" ], "reference_gene_set": "" }, { "gene_set": "IMMPRINT_IL2_SIGNALLING", "gene_symbol": "CSF2", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "24944195" ], "reference_gene_set": "" }, { "gene_set": "IMMPRINT_IL12_SIGNALLING", "gene_symbol": "CSF2", "pathway_level": 3, "pathway_level_label": "Effector", "regulatory_role": "none", "cell_type": "pan", "pmids": [ "24944195" ], "reference_gene_set": "" } ] }